DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

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Auteurs principaux: Xiao Xiao, Jiankai Liang, Chunlong Huang, Kai Li, Fan Xing, Wenbo Zhu, Ziqing Lin, Wencang Xu, Guangen Wu, Jifu Zhang, Xi Lin, Yaqian Tan, Jing Cai, Jun Hu, Xueqin Chen, Youwei Huang, Zixi Qin, Pengxin Qiu, Xingwen Su, Lijun Chen, Yuan Lin, Haipeng Zhang, Guangmei Yan
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/dbf1917a6c734ba89788a062a0d2b470
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Résumé:Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

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