DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

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Autores principales: Xiao Xiao, Jiankai Liang, Chunlong Huang, Kai Li, Fan Xing, Wenbo Zhu, Ziqing Lin, Wencang Xu, Guangen Wu, Jifu Zhang, Xi Lin, Yaqian Tan, Jing Cai, Jun Hu, Xueqin Chen, Youwei Huang, Zixi Qin, Pengxin Qiu, Xingwen Su, Lijun Chen, Yuan Lin, Haipeng Zhang, Guangmei Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dbf1917a6c734ba89788a062a0d2b470
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spelling oai:doaj.org-article:dbf1917a6c734ba89788a062a0d2b4702021-12-02T15:33:44ZDNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage10.1038/s41467-018-06771-42041-1723https://doaj.org/article/dbf1917a6c734ba89788a062a0d2b4702018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06771-4https://doaj.org/toc/2041-1723Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.Xiao XiaoJiankai LiangChunlong HuangKai LiFan XingWenbo ZhuZiqing LinWencang XuGuangen WuJifu ZhangXi LinYaqian TanJing CaiJun HuXueqin ChenYouwei HuangZixi QinPengxin QiuXingwen SuLijun ChenYuan LinHaipeng ZhangGuangmei YanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiao Xiao
Jiankai Liang
Chunlong Huang
Kai Li
Fan Xing
Wenbo Zhu
Ziqing Lin
Wencang Xu
Guangen Wu
Jifu Zhang
Xi Lin
Yaqian Tan
Jing Cai
Jun Hu
Xueqin Chen
Youwei Huang
Zixi Qin
Pengxin Qiu
Xingwen Su
Lijun Chen
Yuan Lin
Haipeng Zhang
Guangmei Yan
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
description Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.
format article
author Xiao Xiao
Jiankai Liang
Chunlong Huang
Kai Li
Fan Xing
Wenbo Zhu
Ziqing Lin
Wencang Xu
Guangen Wu
Jifu Zhang
Xi Lin
Yaqian Tan
Jing Cai
Jun Hu
Xueqin Chen
Youwei Huang
Zixi Qin
Pengxin Qiu
Xingwen Su
Lijun Chen
Yuan Lin
Haipeng Zhang
Guangmei Yan
author_facet Xiao Xiao
Jiankai Liang
Chunlong Huang
Kai Li
Fan Xing
Wenbo Zhu
Ziqing Lin
Wencang Xu
Guangen Wu
Jifu Zhang
Xi Lin
Yaqian Tan
Jing Cai
Jun Hu
Xueqin Chen
Youwei Huang
Zixi Qin
Pengxin Qiu
Xingwen Su
Lijun Chen
Yuan Lin
Haipeng Zhang
Guangmei Yan
author_sort Xiao Xiao
title DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
title_short DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
title_full DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
title_fullStr DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
title_full_unstemmed DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
title_sort dna-pk inhibition synergizes with oncolytic virus m1 by inhibiting antiviral response and potentiating dna damage
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/dbf1917a6c734ba89788a062a0d2b470
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