Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder, predominantly symmetric, which causes joint inflammation, cartilage degeneration and bone erosion, resulting in deformity and the loss of physical function. Although the management of RA has steadily improved, the pathophysiologi...

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Autores principales:	Tapan Behl, Tanuj Upadhyay, Sukhbir Singh, Sridevi Chigurupati, Amal M. Alsubayiel, Vasudevan Mani, Celia Vargas-De-La-Cruz, Diana Uivarosan, Cristiana Bustea, Cristian Sava, Manuela Stoicescu, Andrei-Flavius Radu, Simona Gabriela Bungau
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	rheumatoid arthritis TLR/MAPK flavonoids stilbenes interleukin TNF Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/dbf1da71a03447a984b710d74be09438
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spelling	oai:doaj.org-article:dbf1da71a03447a984b710d74be094382021-11-11T18:33:12ZPolyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis10.3390/molecules262165701420-3049https://doaj.org/article/dbf1da71a03447a984b710d74be094382021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6570https://doaj.org/toc/1420-3049Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder, predominantly symmetric, which causes joint inflammation, cartilage degeneration and bone erosion, resulting in deformity and the loss of physical function. Although the management of RA has steadily improved, the pathophysiological mechanism is incompletely elucidated, and therapeutic options are still limited. Due to shortcomings in the efficacy or safety profiles of conventional RA therapies, therapeutic alternatives have been considered. Therefore, natural extracts containing polyphenolic compounds can become promising adjuvant agents for RA global management, due to their antioxidant, anti-inflammatory and apoptotic properties. Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-κB), and c-Jun N-terminal kinases (JNK)). The critical function of the Toll like-receptor (TLR)-dependent mitogen-activating protein kinase (MAPK) signaling pathway in mediating the pathogenic characteristics of RA has been briefly discussed. Oxidative stress can trigger a change in transcription factors, which leads to the different expression of some genes involved in the inflammatory process. This review aims to provide a comprehensive perspective on the efficacy of polyphenols in mitigating RA by inhibiting signaling pathways, suggesting future research perspectives in order to validate their use.Tapan BehlTanuj UpadhyaySukhbir SinghSridevi ChigurupatiAmal M. AlsubayielVasudevan ManiCelia Vargas-De-La-CruzDiana UivarosanCristiana BusteaCristian SavaManuela StoicescuAndrei-Flavius RaduSimona Gabriela BungauMDPI AGarticlerheumatoid arthritisTLR/MAPKflavonoidsstilbenesinterleukinTNFOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6570, p 6570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis TLR/MAPK flavonoids stilbenes interleukin TNF Organic chemistry QD241-441
spellingShingle	rheumatoid arthritis TLR/MAPK flavonoids stilbenes interleukin TNF Organic chemistry QD241-441 Tapan Behl Tanuj Upadhyay Sukhbir Singh Sridevi Chigurupati Amal M. Alsubayiel Vasudevan Mani Celia Vargas-De-La-Cruz Diana Uivarosan Cristiana Bustea Cristian Sava Manuela Stoicescu Andrei-Flavius Radu Simona Gabriela Bungau Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
description	Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder, predominantly symmetric, which causes joint inflammation, cartilage degeneration and bone erosion, resulting in deformity and the loss of physical function. Although the management of RA has steadily improved, the pathophysiological mechanism is incompletely elucidated, and therapeutic options are still limited. Due to shortcomings in the efficacy or safety profiles of conventional RA therapies, therapeutic alternatives have been considered. Therefore, natural extracts containing polyphenolic compounds can become promising adjuvant agents for RA global management, due to their antioxidant, anti-inflammatory and apoptotic properties. Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-κB), and c-Jun N-terminal kinases (JNK)). The critical function of the Toll like-receptor (TLR)-dependent mitogen-activating protein kinase (MAPK) signaling pathway in mediating the pathogenic characteristics of RA has been briefly discussed. Oxidative stress can trigger a change in transcription factors, which leads to the different expression of some genes involved in the inflammatory process. This review aims to provide a comprehensive perspective on the efficacy of polyphenols in mitigating RA by inhibiting signaling pathways, suggesting future research perspectives in order to validate their use.
format	article
author	Tapan Behl Tanuj Upadhyay Sukhbir Singh Sridevi Chigurupati Amal M. Alsubayiel Vasudevan Mani Celia Vargas-De-La-Cruz Diana Uivarosan Cristiana Bustea Cristian Sava Manuela Stoicescu Andrei-Flavius Radu Simona Gabriela Bungau
author_facet	Tapan Behl Tanuj Upadhyay Sukhbir Singh Sridevi Chigurupati Amal M. Alsubayiel Vasudevan Mani Celia Vargas-De-La-Cruz Diana Uivarosan Cristiana Bustea Cristian Sava Manuela Stoicescu Andrei-Flavius Radu Simona Gabriela Bungau
author_sort	Tapan Behl
title	Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
title_short	Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
title_full	Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
title_fullStr	Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
title_full_unstemmed	Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis
title_sort	polyphenols targeting mapk mediated oxidative stress and inflammation in rheumatoid arthritis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dbf1da71a03447a984b710d74be09438
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Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis

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