Response of Sex Steroid Hormone Synthesis Substrates in Serum and Testes of Male Tilapia (<i>Oreochromis niloticus</i>) Exposed to Methomyl and Its Recovery Pattern
The response of synthetic substrates of sex steroid hormones—cholesterol (CHO), pregnenolone (PREG), and progesterone (PROG)—in the serum and testes of male tilapia (<i>Oreochromis niloticus</i>) to the environmental estrogen pesticide methomyl (0.2, 2, 20, and 200 μg·L<sup>−1</...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/dbf1f132b98a4b219700b80b9c795e86 |
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| Sumario: | The response of synthetic substrates of sex steroid hormones—cholesterol (CHO), pregnenolone (PREG), and progesterone (PROG)—in the serum and testes of male tilapia (<i>Oreochromis niloticus</i>) to the environmental estrogen pesticide methomyl (0.2, 2, 20, and 200 μg·L<sup>−1</sup>) was evaluated using static-water contact toxicity tests. The results showed that low methomyl concentrations (0.2 and 2 μg·L<sup>−1</sup>) had no significant effects on the contents of CHO, PREG, and PROG in the serum and testes of male tilapia (<i>p</i> > 0.05). Consequently, the concentration of 2 μg·L<sup>−1</sup> could be used as a preliminary reference threshold for the non-effective dose of methomyl in male tilapia. Exposure to high methomyl concentrations (20 and 200 μg·L<sup>−1</sup>) significantly inhibited the levels of CHO, PREG, and PROG in the serum and testes of male tilapia (<i>p</i> < 0.05) and showed a dose–response relationship. Sex steroid hormone synthesis substrate damage to male tilapia caused by less than 20 μg·L<sup>−1</sup> methomyl was reversible, while the damage caused by equal to or greater than 200 μg·L<sup>−1</sup> methomyl was irreversible when tilapia were transferred to methomyl-free water for 18 days. Thus, a concentration of 200 μg·L<sup>−1</sup> could be used as a reference threshold for irreversible damage caused by methomyl in male tilapia. |
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