The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease

Abstract Microglial activation is a central player in the pathophysiology of Alzheimer’s disease (AD). The soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) can serve as a marker for microglial activation and has been shown to be overexpressed in AD. However, the relation...

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Autores principales:	So-Hee Park, Eun-Hye Lee, Hyung-Ji Kim, Sungyang Jo, Sunju Lee, Sang Won Seo, Hyun-Hee Park, Seong-Ho Koh, Jae-Hong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dbf6f4fcf5714e81ad60ebe1dc0c2859
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spelling	oai:doaj.org-article:dbf6f4fcf5714e81ad60ebe1dc0c28592021-12-02T17:12:25ZThe relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease10.1038/s41598-021-92101-62045-2322https://doaj.org/article/dbf6f4fcf5714e81ad60ebe1dc0c28592021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92101-6https://doaj.org/toc/2045-2322Abstract Microglial activation is a central player in the pathophysiology of Alzheimer’s disease (AD). The soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) can serve as a marker for microglial activation and has been shown to be overexpressed in AD. However, the relationship of sTREM2 with other AD biomarkers has not been extensively studied. We investigated the relationship between cerebrospinal fluid (CSF) sTREM2 and other AD biomarkers and examined the correlation of plasma sTREM2 with CSF sTREM2 in a cohort of individuals with AD and without AD. Participants were consecutively recruited from Asan Medical Center from 2018 to 2020. Subjects were stratified by their amyloid positivity and clinical status. Along with other AD biomarkers, sTREM2 level was measured in the plasma as well as CSF. In 101 patients with either amyloid-positive or negative status, CSF sTREM2 was closely associated with CSF T-tau and P-tau and not with Abeta42. CSF sTREM2 levels were found to be strongly correlated with CSF neurofilament light chain. The comparison of CSF and plasma sTREM2 levels tended to have an inverse correlation. Plasma sTREM2 and P-tau levels were oppositely influenced by age. Our results suggest that neuroinflammation may be closely associated with tau-induced neurodegeneration.So-Hee ParkEun-Hye LeeHyung-Ji KimSungyang JoSunju LeeSang Won SeoHyun-Hee ParkSeong-Ho KohJae-Hong LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So-Hee Park Eun-Hye Lee Hyung-Ji Kim Sungyang Jo Sunju Lee Sang Won Seo Hyun-Hee Park Seong-Ho Koh Jae-Hong Lee The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
description	Abstract Microglial activation is a central player in the pathophysiology of Alzheimer’s disease (AD). The soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) can serve as a marker for microglial activation and has been shown to be overexpressed in AD. However, the relationship of sTREM2 with other AD biomarkers has not been extensively studied. We investigated the relationship between cerebrospinal fluid (CSF) sTREM2 and other AD biomarkers and examined the correlation of plasma sTREM2 with CSF sTREM2 in a cohort of individuals with AD and without AD. Participants were consecutively recruited from Asan Medical Center from 2018 to 2020. Subjects were stratified by their amyloid positivity and clinical status. Along with other AD biomarkers, sTREM2 level was measured in the plasma as well as CSF. In 101 patients with either amyloid-positive or negative status, CSF sTREM2 was closely associated with CSF T-tau and P-tau and not with Abeta42. CSF sTREM2 levels were found to be strongly correlated with CSF neurofilament light chain. The comparison of CSF and plasma sTREM2 levels tended to have an inverse correlation. Plasma sTREM2 and P-tau levels were oppositely influenced by age. Our results suggest that neuroinflammation may be closely associated with tau-induced neurodegeneration.
format	article
author	So-Hee Park Eun-Hye Lee Hyung-Ji Kim Sungyang Jo Sunju Lee Sang Won Seo Hyun-Hee Park Seong-Ho Koh Jae-Hong Lee
author_facet	So-Hee Park Eun-Hye Lee Hyung-Ji Kim Sungyang Jo Sunju Lee Sang Won Seo Hyun-Hee Park Seong-Ho Koh Jae-Hong Lee
author_sort	So-Hee Park
title	The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
title_short	The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
title_full	The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
title_fullStr	The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
title_full_unstemmed	The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
title_sort	relationship of soluble trem2 to other biomarkers of sporadic alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dbf6f4fcf5714e81ad60ebe1dc0c2859
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The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease

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