Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling

Abstract Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we show that the intera...

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Autores principales: Maria Salmela, Johanna Jokinen, Silja Tiitta, Pekka Rappu, R. Holland Cheng, Jyrki Heino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dbf99cfe587e47e9a99e9658e71ebd1f
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