The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)

Abstract Central airway obstruction (CAO) can be attributed to several benign or malignant conditions. Although surgery is the preferred therapeutic option for the management of CAO, bronchoscopic treatment can be performed in scenarios where the surgical procedure is not possible. Recent years have...

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Autores principales:	Hwa Sik Jung, Ganghee Chae, Jin Hyoung Kim, Chui Yong Park, Soyeoun Lim, Soon Eun Park, Ho Chang Kim, Young Jae Lee, Sung Kwon Kang, Don Han Kim, Yongjik Lee, Taehoon Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dbfaa77322fb45b69e07ec308940838a
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spelling	oai:doaj.org-article:dbfaa77322fb45b69e07ec308940838a2021-12-02T15:51:11ZThe mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)10.1038/s41598-021-87142-w2045-2322https://doaj.org/article/dbfaa77322fb45b69e07ec308940838a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87142-whttps://doaj.org/toc/2045-2322Abstract Central airway obstruction (CAO) can be attributed to several benign or malignant conditions. Although surgery is the preferred therapeutic option for the management of CAO, bronchoscopic treatment can be performed in scenarios where the surgical procedure is not possible. Recent years have witnessed several improvements in the field of bronchoscopic treatment, especially with regard to airway stents. Current research involves new attempts to overcome the existing shortcomings pertaining to the stents (migration, mucostasis, and granulation tissue formation). The authors have recently developed a new silicone airway stent (GINA stent) with an anti-migration design, dynamic structure that enables the reduction of stent cross-sectional area, and radio-opacity. The present study aimed to evaluate the mechanical characteristics and performance of the novel GINA stent using a porcine tracheal stenosis model. In the current study, all the tests involved the comparison of the GINA stent [outer diameter (OD, mm): 14; length (L, mm): 55] with the Dumon stent (OD: 14; L: 50). The mechanical tests were performed using a digital force gauge, in order to determine the anti-migration force, expansion force, and flexibility. The present study evaluated the short-term (3 weeks) performance of the two stents after implantation [GINA (n = 4) vs. Dumon (n = 3)] in the porcine tracheal stenosis model. The results pertaining to the comparison of the mechanical properties of the GINA and Dumon stents are stated as follows: anti-migration force (18.4 vs. 12.8 N, P = 0.008); expansion force (11.9 vs. 14.5 N, P = 0.008); and flexibility (3.1 vs. 4.5 N, P = 0.008). The results pertaining to the comparison of the short-term performance of the GINA and Dumon stents are stated as follows: mucus retention (0/4 vs. 0/3); granulation tissue formation (0/4 vs. 0/3); and migration (1/4 vs. 2/3). The GINA stent displayed better mechanical properties and comparable short-term performance, compared to the Dumon stent.Hwa Sik JungGanghee ChaeJin Hyoung KimChui Yong ParkSoyeoun LimSoon Eun ParkHo Chang KimYoung Jae LeeSung Kwon KangDon Han KimYongjik LeeTaehoon LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hwa Sik Jung Ganghee Chae Jin Hyoung Kim Chui Yong Park Soyeoun Lim Soon Eun Park Ho Chang Kim Young Jae Lee Sung Kwon Kang Don Han Kim Yongjik Lee Taehoon Lee The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
description	Abstract Central airway obstruction (CAO) can be attributed to several benign or malignant conditions. Although surgery is the preferred therapeutic option for the management of CAO, bronchoscopic treatment can be performed in scenarios where the surgical procedure is not possible. Recent years have witnessed several improvements in the field of bronchoscopic treatment, especially with regard to airway stents. Current research involves new attempts to overcome the existing shortcomings pertaining to the stents (migration, mucostasis, and granulation tissue formation). The authors have recently developed a new silicone airway stent (GINA stent) with an anti-migration design, dynamic structure that enables the reduction of stent cross-sectional area, and radio-opacity. The present study aimed to evaluate the mechanical characteristics and performance of the novel GINA stent using a porcine tracheal stenosis model. In the current study, all the tests involved the comparison of the GINA stent [outer diameter (OD, mm): 14; length (L, mm): 55] with the Dumon stent (OD: 14; L: 50). The mechanical tests were performed using a digital force gauge, in order to determine the anti-migration force, expansion force, and flexibility. The present study evaluated the short-term (3 weeks) performance of the two stents after implantation [GINA (n = 4) vs. Dumon (n = 3)] in the porcine tracheal stenosis model. The results pertaining to the comparison of the mechanical properties of the GINA and Dumon stents are stated as follows: anti-migration force (18.4 vs. 12.8 N, P = 0.008); expansion force (11.9 vs. 14.5 N, P = 0.008); and flexibility (3.1 vs. 4.5 N, P = 0.008). The results pertaining to the comparison of the short-term performance of the GINA and Dumon stents are stated as follows: mucus retention (0/4 vs. 0/3); granulation tissue formation (0/4 vs. 0/3); and migration (1/4 vs. 2/3). The GINA stent displayed better mechanical properties and comparable short-term performance, compared to the Dumon stent.
format	article
author	Hwa Sik Jung Ganghee Chae Jin Hyoung Kim Chui Yong Park Soyeoun Lim Soon Eun Park Ho Chang Kim Young Jae Lee Sung Kwon Kang Don Han Kim Yongjik Lee Taehoon Lee
author_facet	Hwa Sik Jung Ganghee Chae Jin Hyoung Kim Chui Yong Park Soyeoun Lim Soon Eun Park Ho Chang Kim Young Jae Lee Sung Kwon Kang Don Han Kim Yongjik Lee Taehoon Lee
author_sort	Hwa Sik Jung
title	The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
title_short	The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
title_full	The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
title_fullStr	The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
title_full_unstemmed	The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)
title_sort	mechanical characteristics and performance evaluation of a newly developed silicone airway stent (gina stent)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dbfaa77322fb45b69e07ec308940838a
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The mechanical characteristics and performance evaluation of a newly developed silicone airway stent (GINA stent)

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