Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort

Introduction: This study aimed to evaluate whether engagement in leisure activities is linked to measures of brain structure, functional connectivity, and cognition in early old age.Methods: We examined data collected from 7,152 participants of the United Kingdom Biobank (UK Biobank) study. Weekly p...

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Autores principales:	Melis Anatürk, Sana Suri, Stephen M. Smith, Klaus P. Ebmeier, Claire E. Sexton
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	leisure activities brain MRI aging cognition UK Biobank Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/dbfcbcca91c64fd188f10c13a946240d
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spelling	oai:doaj.org-article:dbfcbcca91c64fd188f10c13a946240d2021-11-16T05:24:11ZLeisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort1663-436510.3389/fnagi.2021.734866https://doaj.org/article/dbfcbcca91c64fd188f10c13a946240d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.734866/fullhttps://doaj.org/toc/1663-4365Introduction: This study aimed to evaluate whether engagement in leisure activities is linked to measures of brain structure, functional connectivity, and cognition in early old age.Methods: We examined data collected from 7,152 participants of the United Kingdom Biobank (UK Biobank) study. Weekly participation in six leisure activities was assessed twice and a cognitive battery and 3T MRI brain scan were administered at the second visit. Based on responses collected at two time points, individuals were split into one of four trajectory groups: (1) stable low engagement, (2) stable weekly engagement, (3) low to weekly engagement, and (4) weekly to low engagement.Results: Consistent weekly attendance at a sports club or gym was associated with connectivity of the sensorimotor functional network with the lateral visual (β = 0.12, 95%CI = [0.07, 0.18], FDR q = 2.48 × 10–3) and cerebellar (β = 0.12, 95%CI = [0.07, 0.18], FDR q = 1.23 × 10–4) networks. Visiting friends and family across the two timepoints was also associated with larger volumes of the occipital lobe (β = 0.15, 95%CI = [0.08, 0.21], FDR q = 0.03). Additionally, stable and weekly computer use was associated with global cognition (β = 0.62, 95%CI = [0.35, 0.89], FDR q = 1.16 × 10–4). No other associations were significant (FDR q > 0.05).Discussion: This study demonstrates that not all leisure activities contribute to cognitive health equally, nor is there one unifying neural signature across diverse leisure activities.Melis AnatürkMelis AnatürkMelis AnatürkSana SuriSana SuriStephen M. SmithKlaus P. EbmeierClaire E. SextonFrontiers Media S.A.articleleisure activitiesbrainMRIagingcognitionUK BiobankNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leisure activities brain MRI aging cognition UK Biobank Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	leisure activities brain MRI aging cognition UK Biobank Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Melis Anatürk Melis Anatürk Melis Anatürk Sana Suri Sana Suri Stephen M. Smith Klaus P. Ebmeier Claire E. Sexton Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
description	Introduction: This study aimed to evaluate whether engagement in leisure activities is linked to measures of brain structure, functional connectivity, and cognition in early old age.Methods: We examined data collected from 7,152 participants of the United Kingdom Biobank (UK Biobank) study. Weekly participation in six leisure activities was assessed twice and a cognitive battery and 3T MRI brain scan were administered at the second visit. Based on responses collected at two time points, individuals were split into one of four trajectory groups: (1) stable low engagement, (2) stable weekly engagement, (3) low to weekly engagement, and (4) weekly to low engagement.Results: Consistent weekly attendance at a sports club or gym was associated with connectivity of the sensorimotor functional network with the lateral visual (β = 0.12, 95%CI = [0.07, 0.18], FDR q = 2.48 × 10–3) and cerebellar (β = 0.12, 95%CI = [0.07, 0.18], FDR q = 1.23 × 10–4) networks. Visiting friends and family across the two timepoints was also associated with larger volumes of the occipital lobe (β = 0.15, 95%CI = [0.08, 0.21], FDR q = 0.03). Additionally, stable and weekly computer use was associated with global cognition (β = 0.62, 95%CI = [0.35, 0.89], FDR q = 1.16 × 10–4). No other associations were significant (FDR q > 0.05).Discussion: This study demonstrates that not all leisure activities contribute to cognitive health equally, nor is there one unifying neural signature across diverse leisure activities.
format	article
author	Melis Anatürk Melis Anatürk Melis Anatürk Sana Suri Sana Suri Stephen M. Smith Klaus P. Ebmeier Claire E. Sexton
author_facet	Melis Anatürk Melis Anatürk Melis Anatürk Sana Suri Sana Suri Stephen M. Smith Klaus P. Ebmeier Claire E. Sexton
author_sort	Melis Anatürk
title	Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
title_short	Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
title_full	Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
title_fullStr	Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
title_full_unstemmed	Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort
title_sort	leisure activities and their relationship with mri measures of brain structure, functional connectivity, and cognition in the uk biobank cohort
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dbfcbcca91c64fd188f10c13a946240d
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Leisure Activities and Their Relationship With MRI Measures of Brain Structure, Functional Connectivity, and Cognition in the UK Biobank Cohort

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