Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes
Background and Objectives: Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy, but very limited published data have reported in pediatric patients. This study aimed to investigate the etiologic factors, clinical features, and treatment outcomes...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:dc01b3437c3b475ba98a5d29e7e53f322021-12-01T12:42:52ZChoroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes2296-858X10.3389/fmed.2021.735805https://doaj.org/article/dc01b3437c3b475ba98a5d29e7e53f322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.735805/fullhttps://doaj.org/toc/2296-858XBackground and Objectives: Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy, but very limited published data have reported in pediatric patients. This study aimed to investigate the etiologic factors, clinical features, and treatment outcomes of choroidal neovascularization (CNV) in children.Methods: In this study, 33 eyes in 30 patients aged 18 years or younger with CNV were included. Comprehensive ophthalmic examination was performed in all the patients. The demographic profiles, laterality, visual acuity, optical coherence tomographic findings, fundus fluorescein angiographic findings, and the underlying pathology were analyzed. The types, locations, treatment outcomes, and recurrences of CNV were noted.Results: The average age was 11.2 ± 4.6 (range, 1–18) years. Most CNVs affecting children were classic and type 2. The most common etiologic factors of CNV in pediatric patients were congenital/developing abnormalities (9/30, 30.0%) and inflammatory retinochoroidopathy (9/30, 30.0%), followed by idiopathic CNV (8/30, 26.7%). Subtype analysis showed that the etiologic factor was inflammatory retinochoroidopathy in children 12 years or older, whereas congenital/developing abnormalities were present in children younger than 12 years. Eyes with active CNVs required a mean of 1.40 ± 0.58 injections. No recurrence was observed during follow-up.Conclusions: The etiologic factors of CNV in young Chinese patients were diverse, with congenital/developing abnormalities, inflammatory retinochoroidopathy and idiopathic CNV being the 3 most common ones. Eyes with active CNVs had good responses to antivascular endothelial growth factor treatment with low recurrence.Ting ZhangTing ZhangYou WangYou WangWenjia YanWenjia YanYafen LiuYafen LiuJinglin LuJinglin LuLimei SunLimei SunSongshan LiSongshan LiLi HuangLi HuangZhaotian ZhangZhaotian ZhangXiaoyan DingXiaoyan DingFrontiers Media S.A.articlepediatric choroidal neovascularizationetiologic factorcongenital/developing abnormalityinflammatory retinochoroidopathyanti-vascular endothelial growth factorMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
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pediatric choroidal neovascularization etiologic factor congenital/developing abnormality inflammatory retinochoroidopathy anti-vascular endothelial growth factor Medicine (General) R5-920 |
| spellingShingle |
pediatric choroidal neovascularization etiologic factor congenital/developing abnormality inflammatory retinochoroidopathy anti-vascular endothelial growth factor Medicine (General) R5-920 Ting Zhang Ting Zhang You Wang You Wang Wenjia Yan Wenjia Yan Yafen Liu Yafen Liu Jinglin Lu Jinglin Lu Limei Sun Limei Sun Songshan Li Songshan Li Li Huang Li Huang Zhaotian Zhang Zhaotian Zhang Xiaoyan Ding Xiaoyan Ding Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| description |
Background and Objectives: Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy, but very limited published data have reported in pediatric patients. This study aimed to investigate the etiologic factors, clinical features, and treatment outcomes of choroidal neovascularization (CNV) in children.Methods: In this study, 33 eyes in 30 patients aged 18 years or younger with CNV were included. Comprehensive ophthalmic examination was performed in all the patients. The demographic profiles, laterality, visual acuity, optical coherence tomographic findings, fundus fluorescein angiographic findings, and the underlying pathology were analyzed. The types, locations, treatment outcomes, and recurrences of CNV were noted.Results: The average age was 11.2 ± 4.6 (range, 1–18) years. Most CNVs affecting children were classic and type 2. The most common etiologic factors of CNV in pediatric patients were congenital/developing abnormalities (9/30, 30.0%) and inflammatory retinochoroidopathy (9/30, 30.0%), followed by idiopathic CNV (8/30, 26.7%). Subtype analysis showed that the etiologic factor was inflammatory retinochoroidopathy in children 12 years or older, whereas congenital/developing abnormalities were present in children younger than 12 years. Eyes with active CNVs required a mean of 1.40 ± 0.58 injections. No recurrence was observed during follow-up.Conclusions: The etiologic factors of CNV in young Chinese patients were diverse, with congenital/developing abnormalities, inflammatory retinochoroidopathy and idiopathic CNV being the 3 most common ones. Eyes with active CNVs had good responses to antivascular endothelial growth factor treatment with low recurrence. |
| format |
article |
| author |
Ting Zhang Ting Zhang You Wang You Wang Wenjia Yan Wenjia Yan Yafen Liu Yafen Liu Jinglin Lu Jinglin Lu Limei Sun Limei Sun Songshan Li Songshan Li Li Huang Li Huang Zhaotian Zhang Zhaotian Zhang Xiaoyan Ding Xiaoyan Ding |
| author_facet |
Ting Zhang Ting Zhang You Wang You Wang Wenjia Yan Wenjia Yan Yafen Liu Yafen Liu Jinglin Lu Jinglin Lu Limei Sun Limei Sun Songshan Li Songshan Li Li Huang Li Huang Zhaotian Zhang Zhaotian Zhang Xiaoyan Ding Xiaoyan Ding |
| author_sort |
Ting Zhang |
| title |
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| title_short |
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| title_full |
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| title_fullStr |
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| title_full_unstemmed |
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes |
| title_sort |
choroidal neovascularization in pediatric patients: analysis of etiologic factors, clinical characteristics and treatment outcomes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/dc01b3437c3b475ba98a5d29e7e53f32 |
| work_keys_str_mv |
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| _version_ |
1718405204751155200 |