Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles

Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic...

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Autores principales:	Xin Su, Linjian Chen, Xiang Chen, Cuilian Dai, Bin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Materias:	Sortilin dyslipidemia insulin resistance diabetes melitus cardiovascular disease Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc044773080c479e87b15afb73257bf7
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spelling	oai:doaj.org-article:dc044773080c479e87b15afb73257bf72021-11-16T17:17:56ZEmerging roles of sortilin in affecting the metabolism of glucose and lipid profiles10.17305/bjbms.2021.66011512-86011840-4812https://doaj.org/article/dc044773080c479e87b15afb73257bf72021-11-01T00:00:00Zhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/6601https://doaj.org/toc/1512-8601https://doaj.org/toc/1840-4812 Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic syndrome, sortilin has been found in multiple cell types, such as adipocyte, hepatocyte, and macrophage, suggesting that sortilin is correlated to the development and the severity of cardio-metabolic syndrome. Consistently, several genome-wide association (GWAS) and basic experimental research studies are being conducted to find novel gene loci involved in regulating the pathological progression of cardio-metabolic syndrome. According to these data, both SORT1 gene and sortilin protein have an important function in regulating the circulating lipid and glucose metabolism resulting in modulation of disease progression. In this comprehensive review, we summarize the recent research results in regards to sortilin function in modulating the circulating lipid and glucose metabolism. Moreover, we also discuss and analyze the emerging evidence elucidating the potential mechanisms by which sortilin affects synthesis and secretion of lipid and glucose. Xin SuLinjian ChenXiang ChenCuilian DaiBin WangAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaarticleSortilindyslipidemiainsulin resistancediabetes melituscardiovascular diseaseMedicine (General)R5-920ENBosnian Journal of Basic Medical Sciences (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sortilin dyslipidemia insulin resistance diabetes melitus cardiovascular disease Medicine (General) R5-920
spellingShingle	Sortilin dyslipidemia insulin resistance diabetes melitus cardiovascular disease Medicine (General) R5-920 Xin Su Linjian Chen Xiang Chen Cuilian Dai Bin Wang Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
description	Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic syndrome, sortilin has been found in multiple cell types, such as adipocyte, hepatocyte, and macrophage, suggesting that sortilin is correlated to the development and the severity of cardio-metabolic syndrome. Consistently, several genome-wide association (GWAS) and basic experimental research studies are being conducted to find novel gene loci involved in regulating the pathological progression of cardio-metabolic syndrome. According to these data, both SORT1 gene and sortilin protein have an important function in regulating the circulating lipid and glucose metabolism resulting in modulation of disease progression. In this comprehensive review, we summarize the recent research results in regards to sortilin function in modulating the circulating lipid and glucose metabolism. Moreover, we also discuss and analyze the emerging evidence elucidating the potential mechanisms by which sortilin affects synthesis and secretion of lipid and glucose.
format	article
author	Xin Su Linjian Chen Xiang Chen Cuilian Dai Bin Wang
author_facet	Xin Su Linjian Chen Xiang Chen Cuilian Dai Bin Wang
author_sort	Xin Su
title	Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
title_short	Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
title_full	Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
title_fullStr	Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
title_full_unstemmed	Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
title_sort	emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
publishDate	2021
url	https://doaj.org/article/dc044773080c479e87b15afb73257bf7
work_keys_str_mv	AT xinsu emergingrolesofsortilininaffectingthemetabolismofglucoseandlipidprofiles AT linjianchen emergingrolesofsortilininaffectingthemetabolismofglucoseandlipidprofiles AT xiangchen emergingrolesofsortilininaffectingthemetabolismofglucoseandlipidprofiles AT cuiliandai emergingrolesofsortilininaffectingthemetabolismofglucoseandlipidprofiles AT binwang emergingrolesofsortilininaffectingthemetabolismofglucoseandlipidprofiles
_version_	1718426330447478784

Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles

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