The clinical application value of cytokines in treating infectious diseases.

We performed a prospective study to evaluate the abilities of inflammatory cytokines to rule out the potential risk of sepsis and intracranial infection and to estimate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones through ROC analysis. Durin...

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Autores principales:	Qing Ye, Wen-Xia Shao, Xiao-Jun Xu, Ying-zhi Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc05b6702b734848b1a0d6c179984b6b
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spelling	oai:doaj.org-article:dc05b6702b734848b1a0d6c179984b6b2021-11-18T08:17:34ZThe clinical application value of cytokines in treating infectious diseases.1932-620310.1371/journal.pone.0098745https://doaj.org/article/dc05b6702b734848b1a0d6c179984b6b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24887408/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We performed a prospective study to evaluate the abilities of inflammatory cytokines to rule out the potential risk of sepsis and intracranial infection and to estimate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones through ROC analysis. During the course of the study, Levels of serum inflammatory cytokines were measured by flow cytometry at the onset of diseases of patients who suffered from sepsis or intracranial infection. A total of 299 cases of sepsis and 43 cases of intracranial infection were observed during the study. It is noticed that there is no difference of inflammatory cytokine levels between sepsis group and intracranial infection group. The area under ROC curve (AUC) of cytokines, such as IL-2, IL-6 and IL-10 were 0.901, 0.86, 0.888, respectively, which was employed to rule out the diseases of sepsis and intracranial infection. Through comparisons with the patients who were infected by Gram-positive bacteria or Gram-negative ones, it is estimated that IL-6 and IL-10 sharply elevated in patients with Gram-negative bacteria infection (median levels, pg/mL: IL-6: 116.6 vs. 25.4, P = 0.000; IL-10: 13.7 vs. 6.3, P = 0.000). Additionally, IL-2 significantly decreased when patients suffered from Gram-negative bacteria infection (median levels, pg/mL: IL-2: 2.2 vs. 2.7, P = 0.031). The AUCs for detecting cytokines, including IL-2, IL-10 and LOGREGR.Pred_IL-2+IL-10 were 0.581 (95% CI, 0.526 to 0.634), 0.661 (95% CI, 0.608 to 0.712) and 0.735 (95% CI, 0.685 to 0.782), respectively, which was used to evaluate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones infection. This paper indicates that IL-2, IL-6 and IL-10 are effective biomarkers to rule out sepsis and intracranial infection. Additionally, the combination of IL-2 and IL-10 is an effective biomarkers to diagnose whether patients afflicted by Gram-negative bacteria.Qing YeWen-Xia ShaoXiao-Jun XuYing-zhi YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98745 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qing Ye Wen-Xia Shao Xiao-Jun Xu Ying-zhi Yang The clinical application value of cytokines in treating infectious diseases.
description	We performed a prospective study to evaluate the abilities of inflammatory cytokines to rule out the potential risk of sepsis and intracranial infection and to estimate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones through ROC analysis. During the course of the study, Levels of serum inflammatory cytokines were measured by flow cytometry at the onset of diseases of patients who suffered from sepsis or intracranial infection. A total of 299 cases of sepsis and 43 cases of intracranial infection were observed during the study. It is noticed that there is no difference of inflammatory cytokine levels between sepsis group and intracranial infection group. The area under ROC curve (AUC) of cytokines, such as IL-2, IL-6 and IL-10 were 0.901, 0.86, 0.888, respectively, which was employed to rule out the diseases of sepsis and intracranial infection. Through comparisons with the patients who were infected by Gram-positive bacteria or Gram-negative ones, it is estimated that IL-6 and IL-10 sharply elevated in patients with Gram-negative bacteria infection (median levels, pg/mL: IL-6: 116.6 vs. 25.4, P = 0.000; IL-10: 13.7 vs. 6.3, P = 0.000). Additionally, IL-2 significantly decreased when patients suffered from Gram-negative bacteria infection (median levels, pg/mL: IL-2: 2.2 vs. 2.7, P = 0.031). The AUCs for detecting cytokines, including IL-2, IL-10 and LOGREGR.Pred_IL-2+IL-10 were 0.581 (95% CI, 0.526 to 0.634), 0.661 (95% CI, 0.608 to 0.712) and 0.735 (95% CI, 0.685 to 0.782), respectively, which was used to evaluate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones infection. This paper indicates that IL-2, IL-6 and IL-10 are effective biomarkers to rule out sepsis and intracranial infection. Additionally, the combination of IL-2 and IL-10 is an effective biomarkers to diagnose whether patients afflicted by Gram-negative bacteria.
format	article
author	Qing Ye Wen-Xia Shao Xiao-Jun Xu Ying-zhi Yang
author_facet	Qing Ye Wen-Xia Shao Xiao-Jun Xu Ying-zhi Yang
author_sort	Qing Ye
title	The clinical application value of cytokines in treating infectious diseases.
title_short	The clinical application value of cytokines in treating infectious diseases.
title_full	The clinical application value of cytokines in treating infectious diseases.
title_fullStr	The clinical application value of cytokines in treating infectious diseases.
title_full_unstemmed	The clinical application value of cytokines in treating infectious diseases.
title_sort	clinical application value of cytokines in treating infectious diseases.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/dc05b6702b734848b1a0d6c179984b6b
work_keys_str_mv	AT qingye theclinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT wenxiashao theclinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT xiaojunxu theclinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT yingzhiyang theclinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT qingye clinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT wenxiashao clinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT xiaojunxu clinicalapplicationvalueofcytokinesintreatinginfectiousdiseases AT yingzhiyang clinicalapplicationvalueofcytokinesintreatinginfectiousdiseases
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The clinical application value of cytokines in treating infectious diseases.

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