ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin

EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.

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Detalles Bibliográficos
Autores principales:	Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, Luyang Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc073039388d445daa97e34e8864f7eb
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spelling	oai:doaj.org-article:dc073039388d445daa97e34e8864f7eb2021-12-02T17:06:18ZZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin10.1038/s41467-017-00702-52041-1723https://doaj.org/article/dc073039388d445daa97e34e8864f7eb2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00702-5https://doaj.org/toc/2041-1723EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.Lifang LiXinhua LiuLin HeJianguo YangFei PeiWanjin LiShumeng LiuZhe ChenGuojia XieBosen XuXia TingZihan ZhangTong JinXujun LiuWenting ZhangShuai YuanZiran YangChongyang WuYu ZhangXiaohan YangXia YiJing LiangYongfeng ShangLuyang SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lifang Li Xinhua Liu Lin He Jianguo Yang Fei Pei Wanjin Li Shumeng Liu Zhe Chen Guojia Xie Bosen Xu Xia Ting Zihan Zhang Tong Jin Xujun Liu Wenting Zhang Shuai Yuan Ziran Yang Chongyang Wu Yu Zhang Xiaohan Yang Xia Yi Jing Liang Yongfeng Shang Luyang Sun ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
description	EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.
format	article
author	Lifang Li Xinhua Liu Lin He Jianguo Yang Fei Pei Wanjin Li Shumeng Liu Zhe Chen Guojia Xie Bosen Xu Xia Ting Zihan Zhang Tong Jin Xujun Liu Wenting Zhang Shuai Yuan Ziran Yang Chongyang Wu Yu Zhang Xiaohan Yang Xia Yi Jing Liang Yongfeng Shang Luyang Sun
author_facet	Lifang Li Xinhua Liu Lin He Jianguo Yang Fei Pei Wanjin Li Shumeng Liu Zhe Chen Guojia Xie Bosen Xu Xia Ting Zihan Zhang Tong Jin Xujun Liu Wenting Zhang Shuai Yuan Ziran Yang Chongyang Wu Yu Zhang Xiaohan Yang Xia Yi Jing Liang Yongfeng Shang Luyang Sun
author_sort	Lifang Li
title	ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
title_short	ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
title_full	ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
title_fullStr	ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
title_full_unstemmed	ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
title_sort	znf516 suppresses egfr by targeting the ctbp/lsd1/corest complex to chromatin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc073039388d445daa97e34e8864f7eb
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ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin

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