The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog
Nanog regulates embryonic stem cell (ESC) pluripotency but what controls Nanog protein stability is unclear. Here, the authors show that in mouse ESCs, Nanog protein is ubiquitinated and stabilized by the deubiquitinase USP21, which in turn is regulated by extrinsic signals, STAT3 and ERK.
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Nature Portfolio
2016
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oai:doaj.org-article:dc07ba8aadb9427bb2f729c5fdba7e202021-12-02T17:32:50ZThe deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog10.1038/ncomms135942041-1723https://doaj.org/article/dc07ba8aadb9427bb2f729c5fdba7e202016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13594https://doaj.org/toc/2041-1723Nanog regulates embryonic stem cell (ESC) pluripotency but what controls Nanog protein stability is unclear. Here, the authors show that in mouse ESCs, Nanog protein is ubiquitinated and stabilized by the deubiquitinase USP21, which in turn is regulated by extrinsic signals, STAT3 and ERK.Jiali JinJian LiuCong ChenZhenping LiuCong JiangHongshang ChuWeijuan PanXinbo WangLingqiang ZhangBin LiCizhong JiangXin GeXin XiePing WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q Jiali Jin Jian Liu Cong Chen Zhenping Liu Cong Jiang Hongshang Chu Weijuan Pan Xinbo Wang Lingqiang Zhang Bin Li Cizhong Jiang Xin Ge Xin Xie Ping Wang The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| description |
Nanog regulates embryonic stem cell (ESC) pluripotency but what controls Nanog protein stability is unclear. Here, the authors show that in mouse ESCs, Nanog protein is ubiquitinated and stabilized by the deubiquitinase USP21, which in turn is regulated by extrinsic signals, STAT3 and ERK. |
| format |
article |
| author |
Jiali Jin Jian Liu Cong Chen Zhenping Liu Cong Jiang Hongshang Chu Weijuan Pan Xinbo Wang Lingqiang Zhang Bin Li Cizhong Jiang Xin Ge Xin Xie Ping Wang |
| author_facet |
Jiali Jin Jian Liu Cong Chen Zhenping Liu Cong Jiang Hongshang Chu Weijuan Pan Xinbo Wang Lingqiang Zhang Bin Li Cizhong Jiang Xin Ge Xin Xie Ping Wang |
| author_sort |
Jiali Jin |
| title |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| title_short |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| title_full |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| title_fullStr |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| title_full_unstemmed |
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog |
| title_sort |
deubiquitinase usp21 maintains the stemness of mouse embryonic stem cells via stabilization of nanog |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/dc07ba8aadb9427bb2f729c5fdba7e20 |
| work_keys_str_mv |
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