FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA

On the basis of studying of features of structure of 7 genes determining major factors of pathogenicity of the causative agent of whooping cough - ptxA, ptxB, ptxC, ptxD, ptxE, ptxP and prn, features of genotyping variability of strains of B.pertussis allocated from patients with whooping cough in R...

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Autores principales:	V. A. Aleshkin, O. Yu. Borisova, N. T. Gadua, I. K. Mazurova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	bordetella pertussis genotyping gene alleles Science Q
Acceso en línea:	https://doaj.org/article/dc0d3cdd2ff542d587c7e54d3f4960c6
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spelling	oai:doaj.org-article:dc0d3cdd2ff542d587c7e54d3f4960c62021-11-23T06:14:23ZFEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA2541-94202587-9596https://doaj.org/article/dc0d3cdd2ff542d587c7e54d3f4960c62012-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1121https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596On the basis of studying of features of structure of 7 genes determining major factors of pathogenicity of the causative agent of whooping cough - ptxA, ptxB, ptxC, ptxD, ptxE, ptxP and prn, features of genotyping variability of strains of B.pertussis allocated from patients with whooping cough in Russia are shown. Dynamics of formation of population of strains of the causative agent of whooping cough is tracked and is established that population of strains of B.pertussis is formed by clonal expansion of strains with, new genetic structure of major factors of pathogenicity - pertussis toxin and. pertactin. The structure of population of strains of B.pertussis causing a disease by whooping cough, at the present stage of epidemic process of a pertussis infection - domination. of strains with new «non-vaccine» alleles genes - ptxA1 (97,7 %), ptxC2 (87,4 %), prn2 (89,5 %) and. ptxP3 (93,3 %), in 2,2 % cases with ptxB2 allele and. in 1,3 % cases with. prn9 allele circulate.V. A. AleshkinO. Yu. BorisovaN. T. GaduaI. K. MazurovaScientific Сentre for Family Health and Human Reproduction Problemsarticlebordetella pertussisbordetella pertussisgenotypinggeneallelesScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5(1), Pp 177-183 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	bordetella pertussis bordetella pertussis genotyping gene alleles Science Q
spellingShingle	bordetella pertussis bordetella pertussis genotyping gene alleles Science Q V. A. Aleshkin O. Yu. Borisova N. T. Gadua I. K. Mazurova FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
description	On the basis of studying of features of structure of 7 genes determining major factors of pathogenicity of the causative agent of whooping cough - ptxA, ptxB, ptxC, ptxD, ptxE, ptxP and prn, features of genotyping variability of strains of B.pertussis allocated from patients with whooping cough in Russia are shown. Dynamics of formation of population of strains of the causative agent of whooping cough is tracked and is established that population of strains of B.pertussis is formed by clonal expansion of strains with, new genetic structure of major factors of pathogenicity - pertussis toxin and. pertactin. The structure of population of strains of B.pertussis causing a disease by whooping cough, at the present stage of epidemic process of a pertussis infection - domination. of strains with new «non-vaccine» alleles genes - ptxA1 (97,7 %), ptxC2 (87,4 %), prn2 (89,5 %) and. ptxP3 (93,3 %), in 2,2 % cases with ptxB2 allele and. in 1,3 % cases with. prn9 allele circulate.
format	article
author	V. A. Aleshkin O. Yu. Borisova N. T. Gadua I. K. Mazurova
author_facet	V. A. Aleshkin O. Yu. Borisova N. T. Gadua I. K. Mazurova
author_sort	V. A. Aleshkin
title	FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
title_short	FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
title_full	FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
title_fullStr	FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
title_full_unstemmed	FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA
title_sort	features of genotyping variability of strains of bordetella pertussis allocated from patients with whooping cough in russia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/dc0d3cdd2ff542d587c7e54d3f4960c6
work_keys_str_mv	AT vaaleshkin featuresofgenotypingvariabilityofstrainsofbordetellapertussisallocatedfrompatientswithwhoopingcoughinrussia AT oyuborisova featuresofgenotypingvariabilityofstrainsofbordetellapertussisallocatedfrompatientswithwhoopingcoughinrussia AT ntgadua featuresofgenotypingvariabilityofstrainsofbordetellapertussisallocatedfrompatientswithwhoopingcoughinrussia AT ikmazurova featuresofgenotypingvariabilityofstrainsofbordetellapertussisallocatedfrompatientswithwhoopingcoughinrussia
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FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA

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