FICD activity and AMPylation remodelling modulate human neurogenesis

Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate the role of FICD in neuronal differentiation using c...

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Autores principales:	Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc0d7f0727124aa5ad2c40e99753071c
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spelling	oai:doaj.org-article:dc0d7f0727124aa5ad2c40e99753071c2021-12-02T14:41:14ZFICD activity and AMPylation remodelling modulate human neurogenesis10.1038/s41467-019-14235-62041-1723https://doaj.org/article/dc0d7f0727124aa5ad2c40e99753071c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14235-6https://doaj.org/toc/2041-1723Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate the role of FICD in neuronal differentiation using cerebral organoids.Pavel KielkowskiIsabel Y. BuchsbaumVolker C. KirschNina C. BachMicha DrukkerSilvia CappelloStephan A. SieberNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pavel Kielkowski Isabel Y. Buchsbaum Volker C. Kirsch Nina C. Bach Micha Drukker Silvia Cappello Stephan A. Sieber FICD activity and AMPylation remodelling modulate human neurogenesis
description	Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate the role of FICD in neuronal differentiation using cerebral organoids.
format	article
author	Pavel Kielkowski Isabel Y. Buchsbaum Volker C. Kirsch Nina C. Bach Micha Drukker Silvia Cappello Stephan A. Sieber
author_facet	Pavel Kielkowski Isabel Y. Buchsbaum Volker C. Kirsch Nina C. Bach Micha Drukker Silvia Cappello Stephan A. Sieber
author_sort	Pavel Kielkowski
title	FICD activity and AMPylation remodelling modulate human neurogenesis
title_short	FICD activity and AMPylation remodelling modulate human neurogenesis
title_full	FICD activity and AMPylation remodelling modulate human neurogenesis
title_fullStr	FICD activity and AMPylation remodelling modulate human neurogenesis
title_full_unstemmed	FICD activity and AMPylation remodelling modulate human neurogenesis
title_sort	ficd activity and ampylation remodelling modulate human neurogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dc0d7f0727124aa5ad2c40e99753071c
work_keys_str_mv	AT pavelkielkowski ficdactivityandampylationremodellingmodulatehumanneurogenesis AT isabelybuchsbaum ficdactivityandampylationremodellingmodulatehumanneurogenesis AT volkerckirsch ficdactivityandampylationremodellingmodulatehumanneurogenesis AT ninacbach ficdactivityandampylationremodellingmodulatehumanneurogenesis AT michadrukker ficdactivityandampylationremodellingmodulatehumanneurogenesis AT silviacappello ficdactivityandampylationremodellingmodulatehumanneurogenesis AT stephanasieber ficdactivityandampylationremodellingmodulatehumanneurogenesis
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FICD activity and AMPylation remodelling modulate human neurogenesis

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