COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR

The corepressor NCoR is required for tamoxifen-mediated ERα-dependent transcriptional repression. Here, the authors show that COPS5 confers tamoxifen-resistance through the degradation of NCOR, the recruitment of the co-activator PCAF to ERα binding sites and the subsequent ERα transcriptional activ...

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Autores principales:	Renquan Lu, Xiaobo Hu, Junmei Zhou, Jiajun Sun, Alan Z. Zhu, Xiaofeng Xu, Hui Zheng, Xiang Gao, Xian Wang, Hongchuan Jin, Ping Zhu, Lin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc0ed7d3556048dcb203fe789233cfd6
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spelling	oai:doaj.org-article:dc0ed7d3556048dcb203fe789233cfd62021-12-02T15:33:48ZCOPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR10.1038/ncomms120442041-1723https://doaj.org/article/dc0ed7d3556048dcb203fe789233cfd62016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12044https://doaj.org/toc/2041-1723The corepressor NCoR is required for tamoxifen-mediated ERα-dependent transcriptional repression. Here, the authors show that COPS5 confers tamoxifen-resistance through the degradation of NCOR, the recruitment of the co-activator PCAF to ERα binding sites and the subsequent ERα transcriptional activity.Renquan LuXiaobo HuJunmei ZhouJiajun SunAlan Z. ZhuXiaofeng XuHui ZhengXiang GaoXian WangHongchuan JinPing ZhuLin GuoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renquan Lu Xiaobo Hu Junmei Zhou Jiajun Sun Alan Z. Zhu Xiaofeng Xu Hui Zheng Xiang Gao Xian Wang Hongchuan Jin Ping Zhu Lin Guo COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
description	The corepressor NCoR is required for tamoxifen-mediated ERα-dependent transcriptional repression. Here, the authors show that COPS5 confers tamoxifen-resistance through the degradation of NCOR, the recruitment of the co-activator PCAF to ERα binding sites and the subsequent ERα transcriptional activity.
format	article
author	Renquan Lu Xiaobo Hu Junmei Zhou Jiajun Sun Alan Z. Zhu Xiaofeng Xu Hui Zheng Xiang Gao Xian Wang Hongchuan Jin Ping Zhu Lin Guo
author_facet	Renquan Lu Xiaobo Hu Junmei Zhou Jiajun Sun Alan Z. Zhu Xiaofeng Xu Hui Zheng Xiang Gao Xian Wang Hongchuan Jin Ping Zhu Lin Guo
author_sort	Renquan Lu
title	COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
title_short	COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
title_full	COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
title_fullStr	COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
title_full_unstemmed	COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR
title_sort	cops5 amplification and overexpression confers tamoxifen-resistance in erα-positive breast cancer by degradation of ncor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dc0ed7d3556048dcb203fe789233cfd6
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COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR

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