The role of peripheral type 2 innate lymphoid cells in bronchiolitis

Abstract Our aim was to detect type 2 innate lymphoid cells (ILC2s)-related cytokines of infants with bronchiolitis by using Elisa, Liquidchip technology and RT-PCR and investigated its correlation with bronchiolitis. We recruited 26 infants with bronchiolitis and 20 healthy infants as control from...

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Autores principales:	Yong-Jun Tang, Li-Li Xie, Xiang-Rong Zheng, Chen-Tao Liu, Xia Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc18053bdde64476949e9556bdf6f6a3
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spelling	oai:doaj.org-article:dc18053bdde64476949e9556bdf6f6a32021-12-02T13:57:59ZThe role of peripheral type 2 innate lymphoid cells in bronchiolitis10.1038/s41598-021-82096-52045-2322https://doaj.org/article/dc18053bdde64476949e9556bdf6f6a32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82096-5https://doaj.org/toc/2045-2322Abstract Our aim was to detect type 2 innate lymphoid cells (ILC2s)-related cytokines of infants with bronchiolitis by using Elisa, Liquidchip technology and RT-PCR and investigated its correlation with bronchiolitis. We recruited 26 infants with bronchiolitis and 20 healthy infants as control from Xiangya Hospital. Compared to the control group, the serum levels of interleukin-5 (IL-5) [41.99 (21.11) vs 25.70 (19.64)], IL-9 [27.04 (37.51) vs 8.30 (0.54)], IL-13 [184.05 (132.81) vs 121.75 (176.13)], IL-33 [83.70 (46.69) vs 11.23 (55.31)] and thymic stromal lymphopoietin (TSLP) [31.42 (5.41) vs 28.76 (2.56)] were significantly increased in infants with bronchiolitis (P < 0.05), while the level of IgE had no significant difference between the two groups [19.05 (14.15) vs 14.85 (20.2), P > 0.05]. The mRNA expression of IL-17RB (9.83 ± 0.35 vs 9.19 ± 0.58), TSLP (16.98 ± 2.12 vs 15.07 ± 2.25), retinoid acid receptor related orphan receptor α (7.18 ± 0.71 vs 5.46 ± 1.09) and trans-acting T-cell-specific transcription factor 3 (4.86 ± 0.66 vs 4.19 ± 0.90) were significantly increased in infants with bronchiolitis versus the control group (P < 0.05), while there was no statistical significance for suppression of tumorigenicity 2 (5.59 ± 0.68 vs 5.41 ± 0.87, P > 0.05). Our findings suggested that ILC2s possibly play a specific role in immunopathology of bronchiolitis.Yong-Jun TangLi-Li XieXiang-Rong ZhengChen-Tao LiuXia WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong-Jun Tang Li-Li Xie Xiang-Rong Zheng Chen-Tao Liu Xia Wang The role of peripheral type 2 innate lymphoid cells in bronchiolitis
description	Abstract Our aim was to detect type 2 innate lymphoid cells (ILC2s)-related cytokines of infants with bronchiolitis by using Elisa, Liquidchip technology and RT-PCR and investigated its correlation with bronchiolitis. We recruited 26 infants with bronchiolitis and 20 healthy infants as control from Xiangya Hospital. Compared to the control group, the serum levels of interleukin-5 (IL-5) [41.99 (21.11) vs 25.70 (19.64)], IL-9 [27.04 (37.51) vs 8.30 (0.54)], IL-13 [184.05 (132.81) vs 121.75 (176.13)], IL-33 [83.70 (46.69) vs 11.23 (55.31)] and thymic stromal lymphopoietin (TSLP) [31.42 (5.41) vs 28.76 (2.56)] were significantly increased in infants with bronchiolitis (P < 0.05), while the level of IgE had no significant difference between the two groups [19.05 (14.15) vs 14.85 (20.2), P > 0.05]. The mRNA expression of IL-17RB (9.83 ± 0.35 vs 9.19 ± 0.58), TSLP (16.98 ± 2.12 vs 15.07 ± 2.25), retinoid acid receptor related orphan receptor α (7.18 ± 0.71 vs 5.46 ± 1.09) and trans-acting T-cell-specific transcription factor 3 (4.86 ± 0.66 vs 4.19 ± 0.90) were significantly increased in infants with bronchiolitis versus the control group (P < 0.05), while there was no statistical significance for suppression of tumorigenicity 2 (5.59 ± 0.68 vs 5.41 ± 0.87, P > 0.05). Our findings suggested that ILC2s possibly play a specific role in immunopathology of bronchiolitis.
format	article
author	Yong-Jun Tang Li-Li Xie Xiang-Rong Zheng Chen-Tao Liu Xia Wang
author_facet	Yong-Jun Tang Li-Li Xie Xiang-Rong Zheng Chen-Tao Liu Xia Wang
author_sort	Yong-Jun Tang
title	The role of peripheral type 2 innate lymphoid cells in bronchiolitis
title_short	The role of peripheral type 2 innate lymphoid cells in bronchiolitis
title_full	The role of peripheral type 2 innate lymphoid cells in bronchiolitis
title_fullStr	The role of peripheral type 2 innate lymphoid cells in bronchiolitis
title_full_unstemmed	The role of peripheral type 2 innate lymphoid cells in bronchiolitis
title_sort	role of peripheral type 2 innate lymphoid cells in bronchiolitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc18053bdde64476949e9556bdf6f6a3
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The role of peripheral type 2 innate lymphoid cells in bronchiolitis

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