The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability to phosphorylate kinetochores independently of...

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Autores principales:	Prasad Trivedi, Anatoly V. Zaytsev, Maxim Godzi, Fazly I. Ataullakhanov, Ekaterina L. Grishchuk, P. Todd Stukenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc1b2464d5e3480a863990aff60e55d7
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spelling	oai:doaj.org-article:dc1b2464d5e3480a863990aff60e55d72021-12-02T17:01:32ZThe binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway10.1038/s41467-019-08418-42041-1723https://doaj.org/article/dc1b2464d5e3480a863990aff60e55d72019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08418-4https://doaj.org/toc/2041-1723How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability to phosphorylate kinetochores independently of tension generated by kinetochore microtubule attachments.Prasad TrivediAnatoly V. ZaytsevMaxim GodziFazly I. AtaullakhanovEkaterina L. GrishchukP. Todd StukenbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prasad Trivedi Anatoly V. Zaytsev Maxim Godzi Fazly I. Ataullakhanov Ekaterina L. Grishchuk P. Todd Stukenberg The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
description	How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability to phosphorylate kinetochores independently of tension generated by kinetochore microtubule attachments.
format	article
author	Prasad Trivedi Anatoly V. Zaytsev Maxim Godzi Fazly I. Ataullakhanov Ekaterina L. Grishchuk P. Todd Stukenberg
author_facet	Prasad Trivedi Anatoly V. Zaytsev Maxim Godzi Fazly I. Ataullakhanov Ekaterina L. Grishchuk P. Todd Stukenberg
author_sort	Prasad Trivedi
title	The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
title_short	The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
title_full	The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
title_fullStr	The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
title_full_unstemmed	The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
title_sort	binding of borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dc1b2464d5e3480a863990aff60e55d7
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The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

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