Triggering factors associated with a new episode of recurrent acute anterior uveitis

Abstract To identify triggering factors for the next inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month us...

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Autores principales:	Nutnicha Neti, Anchisa Pimsri, Sutasinee Boonsopon, Nattaporn Tesavibul, Pitipol Choopong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc1c0a689ba54bceb8cc8830ad6d7166
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spelling	oai:doaj.org-article:dc1c0a689ba54bceb8cc8830ad6d71662021-12-02T17:52:42ZTriggering factors associated with a new episode of recurrent acute anterior uveitis10.1038/s41598-021-91701-62045-2322https://doaj.org/article/dc1c0a689ba54bceb8cc8830ad6d71662021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91701-6https://doaj.org/toc/2045-2322Abstract To identify triggering factors for the next inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month using Srithanya Stress Test (ST-5) and questionnaires about potential triggering factors. Asymptomatic controls were matched for age (± 5 years), sex, and HLA-B27. There were 39 pairs of cases and controls. Patients who recently experienced a uveitis attack demonstrated higher mean ST-5 scores (3.7 ± 2.9 vs 0.7 ± 1.1) and shorter sleep time (6.3 ± 1.4 vs 7.4 ± 0.7 h per day) compared with their controls. In the multivariate conditional logistic regression analysis, ST-5 score ≥ 3 (OR 9.07, 95% CI 1.14–72.16, p = 0.037) and sleep time < 7 h per day (OR 12.12, 95% CI 1.37–107.17, p = 0.025) were more likely to trigger a uveitis attack in RAAU accounted for patients’ age, sex, HLA- B27 positivity, and presence of concurrent anti-inflammatory drugs for co-existing diseases. Other suspected triggering factors were not found to have any significant association. In short, stress and inadequate sleep may lead to the future episode of acute anterior uveitis in RAAU. Both physical and emotional stress management should be advised to RAAU patients to minimize recurrences and further complications.Nutnicha NetiAnchisa PimsriSutasinee BoonsoponNattaporn TesavibulPitipol ChoopongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nutnicha Neti Anchisa Pimsri Sutasinee Boonsopon Nattaporn Tesavibul Pitipol Choopong Triggering factors associated with a new episode of recurrent acute anterior uveitis
description	Abstract To identify triggering factors for the next inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month using Srithanya Stress Test (ST-5) and questionnaires about potential triggering factors. Asymptomatic controls were matched for age (± 5 years), sex, and HLA-B27. There were 39 pairs of cases and controls. Patients who recently experienced a uveitis attack demonstrated higher mean ST-5 scores (3.7 ± 2.9 vs 0.7 ± 1.1) and shorter sleep time (6.3 ± 1.4 vs 7.4 ± 0.7 h per day) compared with their controls. In the multivariate conditional logistic regression analysis, ST-5 score ≥ 3 (OR 9.07, 95% CI 1.14–72.16, p = 0.037) and sleep time < 7 h per day (OR 12.12, 95% CI 1.37–107.17, p = 0.025) were more likely to trigger a uveitis attack in RAAU accounted for patients’ age, sex, HLA- B27 positivity, and presence of concurrent anti-inflammatory drugs for co-existing diseases. Other suspected triggering factors were not found to have any significant association. In short, stress and inadequate sleep may lead to the future episode of acute anterior uveitis in RAAU. Both physical and emotional stress management should be advised to RAAU patients to minimize recurrences and further complications.
format	article
author	Nutnicha Neti Anchisa Pimsri Sutasinee Boonsopon Nattaporn Tesavibul Pitipol Choopong
author_facet	Nutnicha Neti Anchisa Pimsri Sutasinee Boonsopon Nattaporn Tesavibul Pitipol Choopong
author_sort	Nutnicha Neti
title	Triggering factors associated with a new episode of recurrent acute anterior uveitis
title_short	Triggering factors associated with a new episode of recurrent acute anterior uveitis
title_full	Triggering factors associated with a new episode of recurrent acute anterior uveitis
title_fullStr	Triggering factors associated with a new episode of recurrent acute anterior uveitis
title_full_unstemmed	Triggering factors associated with a new episode of recurrent acute anterior uveitis
title_sort	triggering factors associated with a new episode of recurrent acute anterior uveitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc1c0a689ba54bceb8cc8830ad6d7166
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Triggering factors associated with a new episode of recurrent acute anterior uveitis

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