Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.

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Auteurs principaux:	Peiman Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer, Hugues Beauchemin, Riyan Chen, Halil Bagci, Frank J. T. Staal, Jean-François Coté, Tarik Möröy
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/dc1d6a2a5faa46caa688da1feb30cd2a
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spelling	oai:doaj.org-article:dc1d6a2a5faa46caa688da1feb30cd2a2021-12-02T17:02:03ZGfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes10.1038/s41467-019-09273-z2041-1723https://doaj.org/article/dc1d6a2a5faa46caa688da1feb30cd2a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09273-zhttps://doaj.org/toc/2041-1723Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.Peiman ShooshtarizadehAnne HelnessCharles VadnaisNelleke BrouwerHugues BeaucheminRiyan ChenHalil BagciFrank J. T. StaalJean-François CotéTarik MöröyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peiman Shooshtarizadeh Anne Helness Charles Vadnais Nelleke Brouwer Hugues Beauchemin Riyan Chen Halil Bagci Frank J. T. Staal Jean-François Coté Tarik Möröy Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
description	Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.
format	article
author	Peiman Shooshtarizadeh Anne Helness Charles Vadnais Nelleke Brouwer Hugues Beauchemin Riyan Chen Halil Bagci Frank J. T. Staal Jean-François Coté Tarik Möröy
author_facet	Peiman Shooshtarizadeh Anne Helness Charles Vadnais Nelleke Brouwer Hugues Beauchemin Riyan Chen Halil Bagci Frank J. T. Staal Jean-François Coté Tarik Möröy
author_sort	Peiman Shooshtarizadeh
title	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_short	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_full	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_fullStr	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_full_unstemmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_sort	gfi1b regulates the level of wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dc1d6a2a5faa46caa688da1feb30cd2a
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Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

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