Olive oil in the prevention and treatment of osteoporosis after artificial menopause

Olive oil in the prevention and treatment of osteoporosis after artificial menopause

Huilan Liu,* Huijuan Huang,* Boheng Li, Dong Wu, Fengmei Wang, Xiao hua Zheng, Qingxia Chen, Bifang Wu, Xiaojie FanDepartment of Obstetrics and Gynecology, East Hospital, Xiamen University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workPurpose: Th...

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Autores principales: Liu HL, Huang HJ, Li BH, Wu D, Wang FM, Zheng XH, Chen QX, Wu BF, Fan XJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Olive Oil
Prevention
Treatment
Osteoporosis
Artificial Menopause
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/dc1d77133f9b49beb302bc7fadfdf3e5
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spelling oai:doaj.org-article:dc1d77133f9b49beb302bc7fadfdf3e52021-12-02T07:34:01ZOlive oil in the prevention and treatment of osteoporosis after artificial menopause1178-1998https://doaj.org/article/dc1d77133f9b49beb302bc7fadfdf3e52014-12-01T00:00:00Zhttps://www.dovepress.com/olive-oil-in-the-prevention-and-treatment-ofnbsposteoporosis-after-art-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Huilan Liu,* Huijuan Huang,* Boheng Li, Dong Wu, Fengmei Wang, Xiao hua Zheng, Qingxia Chen, Bifang Wu, Xiaojie FanDepartment of Obstetrics and Gynecology, East Hospital, Xiamen University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workPurpose: The goal of this study was to investigate the anti-osteoporosis effect of extra virgin olive oil (EVOO) in vivo, and explore its antioxidant, anti-inflammatory properties in Sprague Dawley rats and its anticancer properties in patients.Materials and methods: A total of 120 healthy female Sprague Dawley rats aged 6 months were divided into four groups: 1) sham-operated control (Sham group, n=30); 2) ovariectomized (OVX group, n=30); 3) ovariectomized rats supplemented with EVOO (OVX + Olive, n=30); 4) ovariectomized rats supplemented with estrogen (OVX + E2, n=30). EVOO and estrogen were administered by oral gavage at a dose of 1 mL/100 g weight on a daily basis for 12 consecutive weeks. Twelve weeks later blood samples were obtained to detect the levels of calcium, alkaline phosphatase, phosphorus, interleukin-6 (IL-6), malonyldialdehyde (MDA), and nitrate content. Dual energy X-ray absorptiometer measured bone mineral density (BMD) of ovariectomized Sprague Dawley rats that had been fed olive oil for 3 months. Blood samples from patients, who regularly consumed olive oil over a 1 year period were also used to measure carbohydrate antigen 125, carcino-embryonic antigen, α-fetoprotein, and carbohydrate antigen 19-9 levels. BMD of lumbar spine and left femur was also evaluated by dual energy X-ray absorptiometry.Results: Animal experiments showed that EVOO significantly increased BMD and decreased phosphatase, alkaline phosphatase, IL-6, MDA, and nitrate levels. However, it had no significant effect on the Ca2+ level. In clinical follow-up, EVOO also improved patient BMD levels on L3, L4, and left femoral neck, and reduced carbohydrate antigen 125, α-fetoprotein, and carcino-embryonic antigen levels. But it had no significant effect on the carbohydrate antigen 19-9 level.Conclusion: EVOO illustrated significant anti-osteoporosis, antioxidant, anti-inflammatory, and anticancer properties in vivo. However, further studies are required to determine the active component(s) responsible for these effects.Keywords: olive oil, prevention, treatment, osteoporosis, artificial menopauseLiu HLHuang HJLi BHWu DWang FMZheng XHChen QXWu BFFan XJDove Medical PressarticleOlive OilPreventionTreatmentOsteoporosisArtificial MenopauseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 2087-2095 (2014)
institution DOAJ
collection DOAJ
language EN
topic Olive Oil
Prevention
Treatment
Osteoporosis
Artificial Menopause
Geriatrics
RC952-954.6
spellingShingle Olive Oil
Prevention
Treatment
Osteoporosis
Artificial Menopause
Geriatrics
RC952-954.6
Liu HL
Huang HJ
Li BH
Wu D
Wang FM
Zheng XH
Chen QX
Wu BF
Fan XJ
Olive oil in the prevention and treatment of osteoporosis after artificial menopause
description Huilan Liu,* Huijuan Huang,* Boheng Li, Dong Wu, Fengmei Wang, Xiao hua Zheng, Qingxia Chen, Bifang Wu, Xiaojie FanDepartment of Obstetrics and Gynecology, East Hospital, Xiamen University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workPurpose: The goal of this study was to investigate the anti-osteoporosis effect of extra virgin olive oil (EVOO) in vivo, and explore its antioxidant, anti-inflammatory properties in Sprague Dawley rats and its anticancer properties in patients.Materials and methods: A total of 120 healthy female Sprague Dawley rats aged 6 months were divided into four groups: 1) sham-operated control (Sham group, n=30); 2) ovariectomized (OVX group, n=30); 3) ovariectomized rats supplemented with EVOO (OVX + Olive, n=30); 4) ovariectomized rats supplemented with estrogen (OVX + E2, n=30). EVOO and estrogen were administered by oral gavage at a dose of 1 mL/100 g weight on a daily basis for 12 consecutive weeks. Twelve weeks later blood samples were obtained to detect the levels of calcium, alkaline phosphatase, phosphorus, interleukin-6 (IL-6), malonyldialdehyde (MDA), and nitrate content. Dual energy X-ray absorptiometer measured bone mineral density (BMD) of ovariectomized Sprague Dawley rats that had been fed olive oil for 3 months. Blood samples from patients, who regularly consumed olive oil over a 1 year period were also used to measure carbohydrate antigen 125, carcino-embryonic antigen, α-fetoprotein, and carbohydrate antigen 19-9 levels. BMD of lumbar spine and left femur was also evaluated by dual energy X-ray absorptiometry.Results: Animal experiments showed that EVOO significantly increased BMD and decreased phosphatase, alkaline phosphatase, IL-6, MDA, and nitrate levels. However, it had no significant effect on the Ca2+ level. In clinical follow-up, EVOO also improved patient BMD levels on L3, L4, and left femoral neck, and reduced carbohydrate antigen 125, α-fetoprotein, and carcino-embryonic antigen levels. But it had no significant effect on the carbohydrate antigen 19-9 level.Conclusion: EVOO illustrated significant anti-osteoporosis, antioxidant, anti-inflammatory, and anticancer properties in vivo. However, further studies are required to determine the active component(s) responsible for these effects.Keywords: olive oil, prevention, treatment, osteoporosis, artificial menopause
format article
author Liu HL
Huang HJ
Li BH
Wu D
Wang FM
Zheng XH
Chen QX
Wu BF
Fan XJ
author_facet Liu HL
Huang HJ
Li BH
Wu D
Wang FM
Zheng XH
Chen QX
Wu BF
Fan XJ
author_sort Liu HL
title Olive oil in the prevention and treatment of osteoporosis after artificial menopause
title_short Olive oil in the prevention and treatment of osteoporosis after artificial menopause
title_full Olive oil in the prevention and treatment of osteoporosis after artificial menopause
title_fullStr Olive oil in the prevention and treatment of osteoporosis after artificial menopause
title_full_unstemmed Olive oil in the prevention and treatment of osteoporosis after artificial menopause
title_sort olive oil in the prevention and treatment of osteoporosis after artificial menopause
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/dc1d77133f9b49beb302bc7fadfdf3e5
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