Development of a root canal treatment model in the rat

Abstract Root canal treatment is performed to treat apical periodontitis, and various procedures and techniques are currently used. Although animal models have been used in the developmental research of root canal treatment, little of this research has used small animals such as rats, because of the...

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Autores principales:	Naomichi Yoneda, Yuichiro Noiri, Saori Matsui, Katsutaka Kuremoto, Hazuki Maezono, Takuya Ishimoto, Takayoshi Nakano, Shigeyuki Ebisu, Mikako Hayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc25eaab102a46a6bfa55f1e7b2c74cb
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spelling	oai:doaj.org-article:dc25eaab102a46a6bfa55f1e7b2c74cb2021-12-02T11:41:08ZDevelopment of a root canal treatment model in the rat10.1038/s41598-017-03628-62045-2322https://doaj.org/article/dc25eaab102a46a6bfa55f1e7b2c74cb2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03628-6https://doaj.org/toc/2045-2322Abstract Root canal treatment is performed to treat apical periodontitis, and various procedures and techniques are currently used. Although animal models have been used in the developmental research of root canal treatment, little of this research has used small animals such as rats, because of their small size. In this study, root canal treatment was performed on the rat mandibular first molar, which had four root canals, using a microscope, and the therapeutic effect was evaluated bacteriologically, radiologically and histopathologically. By performing root canal treatment, the level of bacteria in the mesial root of the treated teeth was reduced by 75% compared with the control. Additionally, the volume of the periapical lesions of the treated teeth as measured by micro-computed tomography decreased significantly 2 weeks after the root canal treatment when compared with the control. Histological evidence of healing was observed in the treatment group 8 weeks after root canal treatment. These results suggest that a root canal treatment model using rats can be used in developmental research for novel methods of root canal treatment.Naomichi YonedaYuichiro NoiriSaori MatsuiKatsutaka KuremotoHazuki MaezonoTakuya IshimotoTakayoshi NakanoShigeyuki EbisuMikako HayashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naomichi Yoneda Yuichiro Noiri Saori Matsui Katsutaka Kuremoto Hazuki Maezono Takuya Ishimoto Takayoshi Nakano Shigeyuki Ebisu Mikako Hayashi Development of a root canal treatment model in the rat
description	Abstract Root canal treatment is performed to treat apical periodontitis, and various procedures and techniques are currently used. Although animal models have been used in the developmental research of root canal treatment, little of this research has used small animals such as rats, because of their small size. In this study, root canal treatment was performed on the rat mandibular first molar, which had four root canals, using a microscope, and the therapeutic effect was evaluated bacteriologically, radiologically and histopathologically. By performing root canal treatment, the level of bacteria in the mesial root of the treated teeth was reduced by 75% compared with the control. Additionally, the volume of the periapical lesions of the treated teeth as measured by micro-computed tomography decreased significantly 2 weeks after the root canal treatment when compared with the control. Histological evidence of healing was observed in the treatment group 8 weeks after root canal treatment. These results suggest that a root canal treatment model using rats can be used in developmental research for novel methods of root canal treatment.
format	article
author	Naomichi Yoneda Yuichiro Noiri Saori Matsui Katsutaka Kuremoto Hazuki Maezono Takuya Ishimoto Takayoshi Nakano Shigeyuki Ebisu Mikako Hayashi
author_facet	Naomichi Yoneda Yuichiro Noiri Saori Matsui Katsutaka Kuremoto Hazuki Maezono Takuya Ishimoto Takayoshi Nakano Shigeyuki Ebisu Mikako Hayashi
author_sort	Naomichi Yoneda
title	Development of a root canal treatment model in the rat
title_short	Development of a root canal treatment model in the rat
title_full	Development of a root canal treatment model in the rat
title_fullStr	Development of a root canal treatment model in the rat
title_full_unstemmed	Development of a root canal treatment model in the rat
title_sort	development of a root canal treatment model in the rat
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc25eaab102a46a6bfa55f1e7b2c74cb
work_keys_str_mv	AT naomichiyoneda developmentofarootcanaltreatmentmodelintherat AT yuichironoiri developmentofarootcanaltreatmentmodelintherat AT saorimatsui developmentofarootcanaltreatmentmodelintherat AT katsutakakuremoto developmentofarootcanaltreatmentmodelintherat AT hazukimaezono developmentofarootcanaltreatmentmodelintherat AT takuyaishimoto developmentofarootcanaltreatmentmodelintherat AT takayoshinakano developmentofarootcanaltreatmentmodelintherat AT shigeyukiebisu developmentofarootcanaltreatmentmodelintherat AT mikakohayashi developmentofarootcanaltreatmentmodelintherat
_version_	1718395489541423104

Development of a root canal treatment model in the rat

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