Random lasing in human tissues embedded with organic dyes for cancer diagnosis

Abstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,...

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Autores principales:	Yu Wang, Zhuojun Duan, Zhu Qiu, Peng Zhang, Jianwei Wu, Dingke Zhang, Tingxiu Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc25f55894264a4883d1a782eea1da52
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spelling	oai:doaj.org-article:dc25f55894264a4883d1a782eea1da522021-12-02T12:30:26ZRandom lasing in human tissues embedded with organic dyes for cancer diagnosis10.1038/s41598-017-08625-32045-2322https://doaj.org/article/dc25f55894264a4883d1a782eea1da522017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08625-3https://doaj.org/toc/2045-2322Abstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB). Hematoxylin and eosin stain images show that there are more laser resonators in cancerous tissues, caused by a large number of disordered scatters. It is also noteworthy that the random lasing thresholds were found to relate to the tumor malignancy grade. Consequently, the resulting typical random lasing resonators differ between cancerous tissues in different malignancy grades. Further studies are warranted to investigate tissue optical spectroscopy in the field of cancer diagnostics.Yu WangZhuojun DuanZhu QiuPeng ZhangJianwei WuDingke ZhangTingxiu XiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Wang Zhuojun Duan Zhu Qiu Peng Zhang Jianwei Wu Dingke Zhang Tingxiu Xiang Random lasing in human tissues embedded with organic dyes for cancer diagnosis
description	Abstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB). Hematoxylin and eosin stain images show that there are more laser resonators in cancerous tissues, caused by a large number of disordered scatters. It is also noteworthy that the random lasing thresholds were found to relate to the tumor malignancy grade. Consequently, the resulting typical random lasing resonators differ between cancerous tissues in different malignancy grades. Further studies are warranted to investigate tissue optical spectroscopy in the field of cancer diagnostics.
format	article
author	Yu Wang Zhuojun Duan Zhu Qiu Peng Zhang Jianwei Wu Dingke Zhang Tingxiu Xiang
author_facet	Yu Wang Zhuojun Duan Zhu Qiu Peng Zhang Jianwei Wu Dingke Zhang Tingxiu Xiang
author_sort	Yu Wang
title	Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_short	Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_full	Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_fullStr	Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_full_unstemmed	Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_sort	random lasing in human tissues embedded with organic dyes for cancer diagnosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc25f55894264a4883d1a782eea1da52
work_keys_str_mv	AT yuwang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT zhuojunduan randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT zhuqiu randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT pengzhang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT jianweiwu randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT dingkezhang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis AT tingxiuxiang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
_version_	1718394366616141824

Random lasing in human tissues embedded with organic dyes for cancer diagnosis

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