Preliminary Assessment of the Anti-inflammatory Activity of New Structural Honokiol Analogs with a 4′-<i>O</i>-(2-Fluoroethyl) Moiety and the Potential of Their <sup>18</sup>F-Labeled Derivatives for Neuroinflammation Imaging

Preliminary Assessment of the Anti-inflammatory Activity of New Structural Honokiol Analogs with a 4′-<i>O</i>-(2-Fluoroethyl) Moiety and the Potential of Their <sup>18</sup>F-Labeled Derivatives for Neuroinflammation Imaging

Neolignans honokiol and 4′-<i>O</i>-methylhonokiol (MH) and their derivatives have pronounced anti-inflammatory activity, as evidenced by numerous pharmacological studies. Literature data suggested that cyclooxygenase type 2 (COX-2) may be a target for these compounds in vitro and in viv...

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Main Authors: Daria D. Vaulina, Kira I. Stosman, Konstantin V. Sivak, Andrey G. Aleksandrov, Nikolai B. Viktorov, Nikolay N. Kuzmich, Mariia M. Kiseleva, Olga F. Kuznetsova, Natalia A. Gomzina
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
structural analogs of honokiol
fluorine-18
neuroinflammation
radioligand
anti-inflammatory activity
cyclooxygenase-2 (COX-2)
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/dc280d6893ef40ce9b8093ad7de45e15
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https://doaj.org/article/dc280d6893ef40ce9b8093ad7de45e15

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