[68] Presence of viable circulating tumour cells in kidney cancer
Objective: To evaluate the presence of circulating tumour cells (CTCs) in the peripheral blood of patients with kidney cancer (KC) and the dependence of CTC quantification of surgery, as the presence of CTCs in the peripheral blood of patients with solid tumours is associated with poor prognosis but...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Taylor & Francis Group
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/dc282b47242a40adba971bb4e556ca70 |
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| Sumario: | Objective: To evaluate the presence of circulating tumour cells (CTCs) in the peripheral blood of patients with kidney cancer (KC) and the dependence of CTC quantification of surgery, as the presence of CTCs in the peripheral blood of patients with solid tumours is associated with poor prognosis but there are limited data concerning the detection of CTCs in KC. Methods: Peripheral blood samples from 45 patients who underwent a surgical procedure were evaluated using size-based separation technology for CTCs. In most of the patients there were the three blood collections. Results: CTCs were detected in 39 (87%) patients with KC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results show that the technology applied in this study can efficiently capture viable tumour cells in the blood that can be cultured, whilst maintaining their original phenotype. This paper discusses the first successful culturing of human circulating kidney cancer cells for further downstream functional and molecular characterisation. |
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