[68] Presence of viable circulating tumour cells in kidney cancer

Objective: To evaluate the presence of circulating tumour cells (CTCs) in the peripheral blood of patients with kidney cancer (KC) and the dependence of CTC quantification of surgery, as the presence of CTCs in the peripheral blood of patients with solid tumours is associated with poor prognosis but...

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Autores principales:	Robert Grill, Katarina Kolostova, Petr Klezl, Jinich Sonsky, Vladimir Bobek
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/dc282b47242a40adba971bb4e556ca70
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spelling	oai:doaj.org-article:dc282b47242a40adba971bb4e556ca702021-12-02T12:02:03Z[68] Presence of viable circulating tumour cells in kidney cancer2090-598X10.1016/j.aju.2018.10.021https://doaj.org/article/dc282b47242a40adba971bb4e556ca702018-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18301153https://doaj.org/toc/2090-598XObjective: To evaluate the presence of circulating tumour cells (CTCs) in the peripheral blood of patients with kidney cancer (KC) and the dependence of CTC quantification of surgery, as the presence of CTCs in the peripheral blood of patients with solid tumours is associated with poor prognosis but there are limited data concerning the detection of CTCs in KC. Methods: Peripheral blood samples from 45 patients who underwent a surgical procedure were evaluated using size-based separation technology for CTCs. In most of the patients there were the three blood collections. Results: CTCs were detected in 39 (87%) patients with KC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results show that the technology applied in this study can efficiently capture viable tumour cells in the blood that can be cultured, whilst maintaining their original phenotype. This paper discusses the first successful culturing of human circulating kidney cancer cells for further downstream functional and molecular characterisation.Robert GrillKatarina KolostovaPetr KlezlJinich SonskyVladimir BobekTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss , Pp S32-S33 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Robert Grill Katarina Kolostova Petr Klezl Jinich Sonsky Vladimir Bobek [68] Presence of viable circulating tumour cells in kidney cancer
description	Objective: To evaluate the presence of circulating tumour cells (CTCs) in the peripheral blood of patients with kidney cancer (KC) and the dependence of CTC quantification of surgery, as the presence of CTCs in the peripheral blood of patients with solid tumours is associated with poor prognosis but there are limited data concerning the detection of CTCs in KC. Methods: Peripheral blood samples from 45 patients who underwent a surgical procedure were evaluated using size-based separation technology for CTCs. In most of the patients there were the three blood collections. Results: CTCs were detected in 39 (87%) patients with KC. Conclusion: CTCs were detected in a higher percentage of patients than in other studies. The results show that the technology applied in this study can efficiently capture viable tumour cells in the blood that can be cultured, whilst maintaining their original phenotype. This paper discusses the first successful culturing of human circulating kidney cancer cells for further downstream functional and molecular characterisation.
format	article
author	Robert Grill Katarina Kolostova Petr Klezl Jinich Sonsky Vladimir Bobek
author_facet	Robert Grill Katarina Kolostova Petr Klezl Jinich Sonsky Vladimir Bobek
author_sort	Robert Grill
title	[68] Presence of viable circulating tumour cells in kidney cancer
title_short	[68] Presence of viable circulating tumour cells in kidney cancer
title_full	[68] Presence of viable circulating tumour cells in kidney cancer
title_fullStr	[68] Presence of viable circulating tumour cells in kidney cancer
title_full_unstemmed	[68] Presence of viable circulating tumour cells in kidney cancer
title_sort	[68] presence of viable circulating tumour cells in kidney cancer
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/dc282b47242a40adba971bb4e556ca70
work_keys_str_mv	AT robertgrill 68presenceofviablecirculatingtumourcellsinkidneycancer AT katarinakolostova 68presenceofviablecirculatingtumourcellsinkidneycancer AT petrklezl 68presenceofviablecirculatingtumourcellsinkidneycancer AT jinichsonsky 68presenceofviablecirculatingtumourcellsinkidneycancer AT vladimirbobek 68presenceofviablecirculatingtumourcellsinkidneycancer
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[68] Presence of viable circulating tumour cells in kidney cancer

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