Nitric oxide as a source for bacterial triazole biosynthesis

How nature creates 1,2,3-triazole ring is a relevant question to N-N bond biosynthesis. Here, the authors report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine and reveal that this can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is u...

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Autores principales:	Guiyun Zhao, Yuan-Yang Guo, Shunyu Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc2b67cb367840399d4e3e65ee938fac
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spelling	oai:doaj.org-article:dc2b67cb367840399d4e3e65ee938fac2021-12-02T14:25:15ZNitric oxide as a source for bacterial triazole biosynthesis10.1038/s41467-020-15420-82041-1723https://doaj.org/article/dc2b67cb367840399d4e3e65ee938fac2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15420-8https://doaj.org/toc/2041-1723How nature creates 1,2,3-triazole ring is a relevant question to N-N bond biosynthesis. Here, the authors report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine and reveal that this can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block.Guiyun ZhaoYuan-Yang GuoShunyu YaoXinjie ShiLongxian LvYi-Ling DuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guiyun Zhao Yuan-Yang Guo Shunyu Yao Xinjie Shi Longxian Lv Yi-Ling Du Nitric oxide as a source for bacterial triazole biosynthesis
description	How nature creates 1,2,3-triazole ring is a relevant question to N-N bond biosynthesis. Here, the authors report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine and reveal that this can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block.
format	article
author	Guiyun Zhao Yuan-Yang Guo Shunyu Yao Xinjie Shi Longxian Lv Yi-Ling Du
author_facet	Guiyun Zhao Yuan-Yang Guo Shunyu Yao Xinjie Shi Longxian Lv Yi-Ling Du
author_sort	Guiyun Zhao
title	Nitric oxide as a source for bacterial triazole biosynthesis
title_short	Nitric oxide as a source for bacterial triazole biosynthesis
title_full	Nitric oxide as a source for bacterial triazole biosynthesis
title_fullStr	Nitric oxide as a source for bacterial triazole biosynthesis
title_full_unstemmed	Nitric oxide as a source for bacterial triazole biosynthesis
title_sort	nitric oxide as a source for bacterial triazole biosynthesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dc2b67cb367840399d4e3e65ee938fac
work_keys_str_mv	AT guiyunzhao nitricoxideasasourceforbacterialtriazolebiosynthesis AT yuanyangguo nitricoxideasasourceforbacterialtriazolebiosynthesis AT shunyuyao nitricoxideasasourceforbacterialtriazolebiosynthesis AT xinjieshi nitricoxideasasourceforbacterialtriazolebiosynthesis AT longxianlv nitricoxideasasourceforbacterialtriazolebiosynthesis AT yilingdu nitricoxideasasourceforbacterialtriazolebiosynthesis
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Nitric oxide as a source for bacterial triazole biosynthesis

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