Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin

Abstract Lipidomics is advantageous in the study of sebum perturbations occurring in acne. An extended evaluation of the sebum lipid profiles in acne-prone sebaceous areas is lacking in dark skin. Yet, there is a void space in understanding how the building blocks of sebum lipids, i.e. individual fa...

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Autores principales:	Obumneme Emeka Okoro, Adebomi Adenle, Matteo Ludovici, Mauro Truglio, Federico Marini, Emanuela Camera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc2b7f2736b145789576e44f4954c2d8
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spelling	oai:doaj.org-article:dc2b7f2736b145789576e44f4954c2d82021-12-02T18:51:47ZLipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin10.1038/s41598-021-96043-x2045-2322https://doaj.org/article/dc2b7f2736b145789576e44f4954c2d82021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96043-xhttps://doaj.org/toc/2045-2322Abstract Lipidomics is advantageous in the study of sebum perturbations occurring in acne. An extended evaluation of the sebum lipid profiles in acne-prone sebaceous areas is lacking in dark skin. Yet, there is a void space in understanding how the building blocks of sebum lipids, i.e. individual fatty acids (FAs), are intertwined with acne-prone skin. We aimed to determine the sebum lipidome in facial areas of adolescents with and without acne in Nigeria. A cross-sectional analytical study was conducted in 60 adolescents/young adults divided in 30 acne patients (15F, 15M) and 30 age and sex-matched controls. Sebum samples obtained from foreheads and cheeks were analysed separately by gas chromatography–mass spectrometry (GCMS) and thin layer chromatography (HPTLC). Distributions of sebum components were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). Sebum incretion in acne was paralleled by significantly higher abundance of triglycerides, wax esters, and squalene together with monounsaturated FAs (MUFAs), and straight chain saturated FAs (SFAs), especially those with odd-carbon chain, i.e. C13:0, C15:0, and C17:0. Profiling weight/weight percentage of individual components revealed that, in acne, the free FAs (FFAs) array was shifted towards higher relative abundance of the SFAs C15:0, C16:0, and C17:0 and lower percentage of the anteiso-branched FFAs with 12, 14, 16, and 18 carbons. In acne patients, MUFAs and PUFAs were quantitatively increased and decreased on foreheads and cheeks, respectively. Relative abundance of fatty alcohols was decreased in acne independent on the site. The results indicated that acne associates with site-specific derangement of the pathways regulating the balance among odd straight-chain and branched-chain SFAs, MUFAs, which included sapienate (C16:1n-10), PUFAs, and squalene.Obumneme Emeka OkoroAdebomi AdenleMatteo LudoviciMauro TruglioFederico MariniEmanuela CameraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Obumneme Emeka Okoro Adebomi Adenle Matteo Ludovici Mauro Truglio Federico Marini Emanuela Camera Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
description	Abstract Lipidomics is advantageous in the study of sebum perturbations occurring in acne. An extended evaluation of the sebum lipid profiles in acne-prone sebaceous areas is lacking in dark skin. Yet, there is a void space in understanding how the building blocks of sebum lipids, i.e. individual fatty acids (FAs), are intertwined with acne-prone skin. We aimed to determine the sebum lipidome in facial areas of adolescents with and without acne in Nigeria. A cross-sectional analytical study was conducted in 60 adolescents/young adults divided in 30 acne patients (15F, 15M) and 30 age and sex-matched controls. Sebum samples obtained from foreheads and cheeks were analysed separately by gas chromatography–mass spectrometry (GCMS) and thin layer chromatography (HPTLC). Distributions of sebum components were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). Sebum incretion in acne was paralleled by significantly higher abundance of triglycerides, wax esters, and squalene together with monounsaturated FAs (MUFAs), and straight chain saturated FAs (SFAs), especially those with odd-carbon chain, i.e. C13:0, C15:0, and C17:0. Profiling weight/weight percentage of individual components revealed that, in acne, the free FAs (FFAs) array was shifted towards higher relative abundance of the SFAs C15:0, C16:0, and C17:0 and lower percentage of the anteiso-branched FFAs with 12, 14, 16, and 18 carbons. In acne patients, MUFAs and PUFAs were quantitatively increased and decreased on foreheads and cheeks, respectively. Relative abundance of fatty alcohols was decreased in acne independent on the site. The results indicated that acne associates with site-specific derangement of the pathways regulating the balance among odd straight-chain and branched-chain SFAs, MUFAs, which included sapienate (C16:1n-10), PUFAs, and squalene.
format	article
author	Obumneme Emeka Okoro Adebomi Adenle Matteo Ludovici Mauro Truglio Federico Marini Emanuela Camera
author_facet	Obumneme Emeka Okoro Adebomi Adenle Matteo Ludovici Mauro Truglio Federico Marini Emanuela Camera
author_sort	Obumneme Emeka Okoro
title	Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
title_short	Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
title_full	Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
title_fullStr	Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
title_full_unstemmed	Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
title_sort	lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc2b7f2736b145789576e44f4954c2d8
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Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin

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