Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Abstract A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence in humans. In spite of intense study, it remains unclear whether the deletion actually reflects adaptation to humans. H...

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Autores principales: Doreen Muth, Victor Max Corman, Hanna Roth, Tabea Binger, Ronald Dijkman, Lina Theresa Gottula, Florian Gloza-Rausch, Andrea Balboni, Mara Battilani, Danijela Rihtarič, Ivan Toplak, Ramón Seage Ameneiros, Alexander Pfeifer, Volker Thiel, Jan Felix Drexler, Marcel Alexander Müller, Christian Drosten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoVs)
Nt Deletion
Human Angiotensin-converting Enzyme
Full ORF8
Human Airway Epithelial Cultures (HAE)
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/dc2eb990e1334c749f38f36a60836653
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