Joint disease-specificity at the regulatory base-pair level

While many genetic loci have been found to be associated with disease, not many have had their causal variants and mechanisms investigated. Here, the authors experimentally dissect two loci near GDF5 which are associated with two different joint disorders and which map to independent regulatory elem...

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Main Authors:	Pushpanathan Muthuirulan, Dewei Zhao, Mariel Young, Daniel Richard, Zun Liu, Alireza Emami, Gabriela Portilla, Shayan Hosseinzadeh, Jiaxue Cao, David Maridas, Mary Sedlak, Danilo Menghini, Liangliang Cheng, Lu Li, Xinjia Ding, Yan Ding, Vicki Rosen, Ata M. Kiapour, Terence D. Capellini
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/dc2f3fa7f95e4a3b81a9ed77b668ef96
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spelling	oai:doaj.org-article:dc2f3fa7f95e4a3b81a9ed77b668ef962021-12-02T15:22:59ZJoint disease-specificity at the regulatory base-pair level10.1038/s41467-021-24345-92041-1723https://doaj.org/article/dc2f3fa7f95e4a3b81a9ed77b668ef962021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24345-9https://doaj.org/toc/2041-1723While many genetic loci have been found to be associated with disease, not many have had their causal variants and mechanisms investigated. Here, the authors experimentally dissect two loci near GDF5 which are associated with two different joint disorders and which map to independent regulatory elements.Pushpanathan MuthuirulanDewei ZhaoMariel YoungDaniel RichardZun LiuAlireza EmamiGabriela PortillaShayan HosseinzadehJiaxue CaoDavid MaridasMary SedlakDanilo MenghiniLiangliang ChengLu LiXinjia DingYan DingVicki RosenAta M. KiapourTerence D. CapelliniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pushpanathan Muthuirulan Dewei Zhao Mariel Young Daniel Richard Zun Liu Alireza Emami Gabriela Portilla Shayan Hosseinzadeh Jiaxue Cao David Maridas Mary Sedlak Danilo Menghini Liangliang Cheng Lu Li Xinjia Ding Yan Ding Vicki Rosen Ata M. Kiapour Terence D. Capellini Joint disease-specificity at the regulatory base-pair level
description	While many genetic loci have been found to be associated with disease, not many have had their causal variants and mechanisms investigated. Here, the authors experimentally dissect two loci near GDF5 which are associated with two different joint disorders and which map to independent regulatory elements.
format	article
author	Pushpanathan Muthuirulan Dewei Zhao Mariel Young Daniel Richard Zun Liu Alireza Emami Gabriela Portilla Shayan Hosseinzadeh Jiaxue Cao David Maridas Mary Sedlak Danilo Menghini Liangliang Cheng Lu Li Xinjia Ding Yan Ding Vicki Rosen Ata M. Kiapour Terence D. Capellini
author_facet	Pushpanathan Muthuirulan Dewei Zhao Mariel Young Daniel Richard Zun Liu Alireza Emami Gabriela Portilla Shayan Hosseinzadeh Jiaxue Cao David Maridas Mary Sedlak Danilo Menghini Liangliang Cheng Lu Li Xinjia Ding Yan Ding Vicki Rosen Ata M. Kiapour Terence D. Capellini
author_sort	Pushpanathan Muthuirulan
title	Joint disease-specificity at the regulatory base-pair level
title_short	Joint disease-specificity at the regulatory base-pair level
title_full	Joint disease-specificity at the regulatory base-pair level
title_fullStr	Joint disease-specificity at the regulatory base-pair level
title_full_unstemmed	Joint disease-specificity at the regulatory base-pair level
title_sort	joint disease-specificity at the regulatory base-pair level
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc2f3fa7f95e4a3b81a9ed77b668ef96
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Joint disease-specificity at the regulatory base-pair level

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