Joint disease-specificity at the regulatory base-pair level

Joint disease-specificity at the regulatory base-pair level

While many genetic loci have been found to be associated with disease, not many have had their causal variants and mechanisms investigated. Here, the authors experimentally dissect two loci near GDF5 which are associated with two different joint disorders and which map to independent regulatory elem...

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Main Authors: Pushpanathan Muthuirulan, Dewei Zhao, Mariel Young, Daniel Richard, Zun Liu, Alireza Emami, Gabriela Portilla, Shayan Hosseinzadeh, Jiaxue Cao, David Maridas, Mary Sedlak, Danilo Menghini, Liangliang Cheng, Lu Li, Xinjia Ding, Yan Ding, Vicki Rosen, Ata M. Kiapour, Terence D. Capellini
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/dc2f3fa7f95e4a3b81a9ed77b668ef96
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