O-GlcNAcylation links oncogenic signals and cancer epigenetics

Abstract Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer therapy. Understanding how conventional oncogenic factors cause epigenetic abnormality is of great basic and translational value. O-GlcNAcylation...

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Autores principales:	Lidong Sun, Suli Lv, Tanjing Song
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	O-GlcNAcylation Hexoamine biosynthesis pathway OGT OGA Histone Chromatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dc30d01016ef408dbf91c92b122331e2
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spelling	oai:doaj.org-article:dc30d01016ef408dbf91c92b122331e22021-11-28T12:42:06ZO-GlcNAcylation links oncogenic signals and cancer epigenetics10.1007/s12672-021-00450-52730-6011https://doaj.org/article/dc30d01016ef408dbf91c92b122331e22021-11-01T00:00:00Zhttps://doi.org/10.1007/s12672-021-00450-5https://doaj.org/toc/2730-6011Abstract Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer therapy. Understanding how conventional oncogenic factors cause epigenetic abnormality is of great basic and translational value. O-GlcNAcylation is a protein modification which affects physiology and pathophysiology. In mammals, O-GlcNAcylation is catalyzed by one single enzyme OGT and removed by one single enzyme OGA. O-GlcNAcylation is affected by the availability of the donor, UDP-GlcNAc, generated by the serial enzymatic reactions in the hexoamine biogenesis pathway (HBP). O-GlcNAcylation regulates a wide spectrum of substrates including many proteins involved in epigenetic modification. Like epigenetic modifications, abnormality of O-GlcNAcylation is also common in cancer. Studies have revealed substantial impact on HBP enzymes and OGT/OGA by oncogenic signals. In this review, we will first summarize how oncogenic signals regulate HBP enzymes, OGT and OGA in cancer. We will then integrate this knowledge with the up to date understanding how O-GlcNAcylation regulates epigenetic machinery. With this, we propose a signal axis from oncogenic signals through O-GlcNAcylation dysregulation to epigenetic abnormality in cancer. Further elucidation of this axis will not only advance our understanding of cancer biology but also provide new revenues towards cancer therapy.Lidong SunSuli LvTanjing SongSpringerarticleO-GlcNAcylationHexoamine biosynthesis pathwayOGTOGAHistoneChromatinNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENDiscover Oncology, Vol 12, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	O-GlcNAcylation Hexoamine biosynthesis pathway OGT OGA Histone Chromatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	O-GlcNAcylation Hexoamine biosynthesis pathway OGT OGA Histone Chromatin Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lidong Sun Suli Lv Tanjing Song O-GlcNAcylation links oncogenic signals and cancer epigenetics
description	Abstract Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer therapy. Understanding how conventional oncogenic factors cause epigenetic abnormality is of great basic and translational value. O-GlcNAcylation is a protein modification which affects physiology and pathophysiology. In mammals, O-GlcNAcylation is catalyzed by one single enzyme OGT and removed by one single enzyme OGA. O-GlcNAcylation is affected by the availability of the donor, UDP-GlcNAc, generated by the serial enzymatic reactions in the hexoamine biogenesis pathway (HBP). O-GlcNAcylation regulates a wide spectrum of substrates including many proteins involved in epigenetic modification. Like epigenetic modifications, abnormality of O-GlcNAcylation is also common in cancer. Studies have revealed substantial impact on HBP enzymes and OGT/OGA by oncogenic signals. In this review, we will first summarize how oncogenic signals regulate HBP enzymes, OGT and OGA in cancer. We will then integrate this knowledge with the up to date understanding how O-GlcNAcylation regulates epigenetic machinery. With this, we propose a signal axis from oncogenic signals through O-GlcNAcylation dysregulation to epigenetic abnormality in cancer. Further elucidation of this axis will not only advance our understanding of cancer biology but also provide new revenues towards cancer therapy.
format	article
author	Lidong Sun Suli Lv Tanjing Song
author_facet	Lidong Sun Suli Lv Tanjing Song
author_sort	Lidong Sun
title	O-GlcNAcylation links oncogenic signals and cancer epigenetics
title_short	O-GlcNAcylation links oncogenic signals and cancer epigenetics
title_full	O-GlcNAcylation links oncogenic signals and cancer epigenetics
title_fullStr	O-GlcNAcylation links oncogenic signals and cancer epigenetics
title_full_unstemmed	O-GlcNAcylation links oncogenic signals and cancer epigenetics
title_sort	o-glcnacylation links oncogenic signals and cancer epigenetics
publisher	Springer
publishDate	2021
url	https://doaj.org/article/dc30d01016ef408dbf91c92b122331e2
work_keys_str_mv	AT lidongsun oglcnacylationlinksoncogenicsignalsandcancerepigenetics AT sulilv oglcnacylationlinksoncogenicsignalsandcancerepigenetics AT tanjingsong oglcnacylationlinksoncogenicsignalsandcancerepigenetics
_version_	1718407861948645376

O-GlcNAcylation links oncogenic signals and cancer epigenetics

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