FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acety...

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Autores principales:	Hanyong Jin, Boeun Lee, Yongyang Luo, Yuri Choi, Eui-Hwan Choi, Hong Jin, Kee-Beom Kim, Sang Beom Seo, Yong-Hak Kim, Hyung Ho Lee, Keun Pil Kim, Kangseok Lee, Jeehyeon Bae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc3287deb2f54cbfa67a690e448af5a2
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id	oai:doaj.org-article:dc3287deb2f54cbfa67a690e448af5a2
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spelling	oai:doaj.org-article:dc3287deb2f54cbfa67a690e448af5a22021-12-02T15:39:28ZFOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku10.1038/s41467-020-15748-12041-1723https://doaj.org/article/dc3287deb2f54cbfa67a690e448af5a22020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15748-1https://doaj.org/toc/2041-1723The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acetylation-dependent binding to Ku.Hanyong JinBoeun LeeYongyang LuoYuri ChoiEui-Hwan ChoiHong JinKee-Beom KimSang Beom SeoYong-Hak KimHyung Ho LeeKeun Pil KimKangseok LeeJeehyeon BaeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanyong Jin Boeun Lee Yongyang Luo Yuri Choi Eui-Hwan Choi Hong Jin Kee-Beom Kim Sang Beom Seo Yong-Hak Kim Hyung Ho Lee Keun Pil Kim Kangseok Lee Jeehyeon Bae FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
description	The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acetylation-dependent binding to Ku.
format	article
author	Hanyong Jin Boeun Lee Yongyang Luo Yuri Choi Eui-Hwan Choi Hong Jin Kee-Beom Kim Sang Beom Seo Yong-Hak Kim Hyung Ho Lee Keun Pil Kim Kangseok Lee Jeehyeon Bae
author_facet	Hanyong Jin Boeun Lee Yongyang Luo Yuri Choi Eui-Hwan Choi Hong Jin Kee-Beom Kim Sang Beom Seo Yong-Hak Kim Hyung Ho Lee Keun Pil Kim Kangseok Lee Jeehyeon Bae
author_sort	Hanyong Jin
title	FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
title_short	FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
title_full	FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
title_fullStr	FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
title_full_unstemmed	FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
title_sort	foxl2 directs dna double-strand break repair pathways by differentially interacting with ku
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dc3287deb2f54cbfa67a690e448af5a2
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FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

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