FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acety...

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Autores principales: Hanyong Jin, Boeun Lee, Yongyang Luo, Yuri Choi, Eui-Hwan Choi, Hong Jin, Kee-Beom Kim, Sang Beom Seo, Yong-Hak Kim, Hyung Ho Lee, Keun Pil Kim, Kangseok Lee, Jeehyeon Bae
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/dc3287deb2f54cbfa67a690e448af5a2
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