Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases

Abstract Patients with inflammatory bowel disease (IBD) report fatigue more frequently than healthy population, but the precise mechanisms underlying its presence are unknown. This study aimed to evaluate the prevalence of fatigue in IBD and its relation with potential causative factors. A survey on...

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Autores principales:	Laura Tasson, Fabiana Zingone, Brigida Barberio, Romina Valentini, Pamela Ballotta, Alexander C. Ford, Marco Scarpa, Imerio Angriman, Matteo Fassan, Edoardo Savarino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc38a481387c4964a46f772fe0a816e4
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spelling	oai:doaj.org-article:dc38a481387c4964a46f772fe0a816e42021-12-02T16:30:10ZSarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases10.1038/s41598-021-94685-52045-2322https://doaj.org/article/dc38a481387c4964a46f772fe0a816e42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94685-5https://doaj.org/toc/2045-2322Abstract Patients with inflammatory bowel disease (IBD) report fatigue more frequently than healthy population, but the precise mechanisms underlying its presence are unknown. This study aimed to evaluate the prevalence of fatigue in IBD and its relation with potential causative factors. A survey on fatigue, depression, anxiety, sleep disorders, and the presence of sarcopenia and malnutrition, was sent by email to 244 IBD outpatients of the Gastroenterology Unit of Academic Hospital of Padua. Demographics and clinical data, including the levels of fecal calprotectin (FC) and C-reactive protein (CRP), and current pharmacological treatments were obtained from patients’ medical records. Ninety-nine (40.5%) subjects answered the survey. Ninety-two (92.9%) patients reported fatigue, with sixty-six having mild to moderate fatigue and twenty-six severe fatigue. Multivariate analysis showed that abnormal values of CRP (OR 5.1), severe anxiety (OR 3.7) and sarcopenia (OR 4.4) were the factors independently associated with severe fatigue. Fatigue has a high prevalence in subject affected by IBD. Subjects with altered CRP, sarcopenia and severe anxiety appear more at risk of severe fatigue.Laura TassonFabiana ZingoneBrigida BarberioRomina ValentiniPamela BallottaAlexander C. FordMarco ScarpaImerio AngrimanMatteo FassanEdoardo SavarinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Tasson Fabiana Zingone Brigida Barberio Romina Valentini Pamela Ballotta Alexander C. Ford Marco Scarpa Imerio Angriman Matteo Fassan Edoardo Savarino Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
description	Abstract Patients with inflammatory bowel disease (IBD) report fatigue more frequently than healthy population, but the precise mechanisms underlying its presence are unknown. This study aimed to evaluate the prevalence of fatigue in IBD and its relation with potential causative factors. A survey on fatigue, depression, anxiety, sleep disorders, and the presence of sarcopenia and malnutrition, was sent by email to 244 IBD outpatients of the Gastroenterology Unit of Academic Hospital of Padua. Demographics and clinical data, including the levels of fecal calprotectin (FC) and C-reactive protein (CRP), and current pharmacological treatments were obtained from patients’ medical records. Ninety-nine (40.5%) subjects answered the survey. Ninety-two (92.9%) patients reported fatigue, with sixty-six having mild to moderate fatigue and twenty-six severe fatigue. Multivariate analysis showed that abnormal values of CRP (OR 5.1), severe anxiety (OR 3.7) and sarcopenia (OR 4.4) were the factors independently associated with severe fatigue. Fatigue has a high prevalence in subject affected by IBD. Subjects with altered CRP, sarcopenia and severe anxiety appear more at risk of severe fatigue.
format	article
author	Laura Tasson Fabiana Zingone Brigida Barberio Romina Valentini Pamela Ballotta Alexander C. Ford Marco Scarpa Imerio Angriman Matteo Fassan Edoardo Savarino
author_facet	Laura Tasson Fabiana Zingone Brigida Barberio Romina Valentini Pamela Ballotta Alexander C. Ford Marco Scarpa Imerio Angriman Matteo Fassan Edoardo Savarino
author_sort	Laura Tasson
title	Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
title_short	Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
title_full	Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
title_fullStr	Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
title_full_unstemmed	Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
title_sort	sarcopenia, severe anxiety and increased c-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc38a481387c4964a46f772fe0a816e4
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Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases

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