Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs

Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis. During the last two decades, DOS has become an unmissable strategy in organic synthesis and is fully integrated in v...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mathias Eymery, Viet-Khoa Tran-Nguyen, Ahcène Boumendjel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Diversity-Oriented Synthesis natural products amino acetophenones flavones aurones coumarins Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/dc39d14d38f4488890e2fd62eeb64766
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dc39d14d38f4488890e2fd62eeb64766
record_format	dspace
spelling	oai:doaj.org-article:dc39d14d38f4488890e2fd62eeb647662021-11-25T18:39:33ZDiversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs10.3390/ph141111271424-8247https://doaj.org/article/dc39d14d38f4488890e2fd62eeb647662021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1127https://doaj.org/toc/1424-8247Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis. During the last two decades, DOS has become an unmissable strategy in organic synthesis and is fully integrated in various drug discovery processes. On the other hand, natural products with multiple relevant pharmacological properties have been extensively investigated as scaffolds for ligand-based drug design. In this article, we report the amino dimethoxyacetophenones that can be easily synthesized and scaled up from the commercially available 3,5-dimethoxyaniline as valuable starting blocks for the DOS of natural product analogs. More focus is placed on the synthesis of analogs of flavones, coumarins, azocanes, chalcones, and aurones, which are frequently studied as lead compounds in drug discovery.Mathias EymeryViet-Khoa Tran-NguyenAhcène BoumendjelMDPI AGarticleDiversity-Oriented Synthesisnatural productsamino acetophenonesflavonesauronescoumarinsMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1127, p 1127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diversity-Oriented Synthesis natural products amino acetophenones flavones aurones coumarins Medicine R Pharmacy and materia medica RS1-441
spellingShingle	Diversity-Oriented Synthesis natural products amino acetophenones flavones aurones coumarins Medicine R Pharmacy and materia medica RS1-441 Mathias Eymery Viet-Khoa Tran-Nguyen Ahcène Boumendjel Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
description	Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis. During the last two decades, DOS has become an unmissable strategy in organic synthesis and is fully integrated in various drug discovery processes. On the other hand, natural products with multiple relevant pharmacological properties have been extensively investigated as scaffolds for ligand-based drug design. In this article, we report the amino dimethoxyacetophenones that can be easily synthesized and scaled up from the commercially available 3,5-dimethoxyaniline as valuable starting blocks for the DOS of natural product analogs. More focus is placed on the synthesis of analogs of flavones, coumarins, azocanes, chalcones, and aurones, which are frequently studied as lead compounds in drug discovery.
format	article
author	Mathias Eymery Viet-Khoa Tran-Nguyen Ahcène Boumendjel
author_facet	Mathias Eymery Viet-Khoa Tran-Nguyen Ahcène Boumendjel
author_sort	Mathias Eymery
title	Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
title_short	Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
title_full	Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
title_fullStr	Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
title_full_unstemmed	Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs
title_sort	diversity-oriented synthesis: amino acetophenones as building blocks for the synthesis of natural product analogs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dc39d14d38f4488890e2fd62eeb64766
work_keys_str_mv	AT mathiaseymery diversityorientedsynthesisaminoacetophenonesasbuildingblocksforthesynthesisofnaturalproductanalogs AT vietkhoatrannguyen diversityorientedsynthesisaminoacetophenonesasbuildingblocksforthesynthesisofnaturalproductanalogs AT ahceneboumendjel diversityorientedsynthesisaminoacetophenonesasbuildingblocksforthesynthesisofnaturalproductanalogs
_version_	1718410866150342656

Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs

Ejemplares similares