Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship

ABSTRACT The intestinal microbiota is highly metabolically active and plays an important role in many metabolic processes absent from the human host. Altered microbiota metabolism has been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. However, there is a gap in t...

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Autores principales:	Ce Yuan, Melanie Graham, Christopher Staley, Subbaya Subramanian
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	microbiota metabolome host-microbiota interactions nonhuman primate prebiotics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/dc3af3965e0247e89a243c91c076acaf
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spelling	oai:doaj.org-article:dc3af3965e0247e89a243c91c076acaf2021-12-02T18:44:35ZMucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship10.1128/mSystems.00055-202379-5077https://doaj.org/article/dc3af3965e0247e89a243c91c076acaf2020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00055-20https://doaj.org/toc/2379-5077ABSTRACT The intestinal microbiota is highly metabolically active and plays an important role in many metabolic processes absent from the human host. Altered microbiota metabolism has been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. However, there is a gap in the current knowledge on how the microbiota interact with its host in terms of metabolic interactions. Here, we performed an integrated analysis between the mucosa-associated microbiota and the mucosa metabolome in healthy, nonhuman primates to investigate these relationships. The microbiota composition was distinct at each tissue location, with variation by host individual also observed. Microbiota-metabolome dynamics were primarily driven by interactions in the distal colon. These interactions were strongly correlated with dietary component, indicating a possibility to modulate microbiota-metabolomic interactions using prebiotic strategies. IMPORTANCE In a healthy colon, the microbiota produces a vast amount of metabolites that are essential to maintaining homeostasis in the colon microenvironment. In fact, these metabolites produced by the microbiota have been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. In this study, we used healthy nonhuman primate models to investigate the relationship between microbiota and tissue metabolites. We found that both microbiota and metabolites have location-specific signatures along the intestine. Most importantly, we found that metabolites from food sources correlate with multiple bacteria in different intestinal locations. Overall, this work presents a systems-level map of the association between the microbiota and the metabolites in healthy nonhuman primates, provides candidates for experimental validation, and suggests a possibility to regulate the gut microbiota through specific prebiotic combinations.Ce YuanMelanie GrahamChristopher StaleySubbaya SubramanianAmerican Society for Microbiologyarticlemicrobiotametabolomehost-microbiota interactionsnonhuman primateprebioticsMicrobiologyQR1-502ENmSystems, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiota metabolome host-microbiota interactions nonhuman primate prebiotics Microbiology QR1-502
spellingShingle	microbiota metabolome host-microbiota interactions nonhuman primate prebiotics Microbiology QR1-502 Ce Yuan Melanie Graham Christopher Staley Subbaya Subramanian Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
description	ABSTRACT The intestinal microbiota is highly metabolically active and plays an important role in many metabolic processes absent from the human host. Altered microbiota metabolism has been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. However, there is a gap in the current knowledge on how the microbiota interact with its host in terms of metabolic interactions. Here, we performed an integrated analysis between the mucosa-associated microbiota and the mucosa metabolome in healthy, nonhuman primates to investigate these relationships. The microbiota composition was distinct at each tissue location, with variation by host individual also observed. Microbiota-metabolome dynamics were primarily driven by interactions in the distal colon. These interactions were strongly correlated with dietary component, indicating a possibility to modulate microbiota-metabolomic interactions using prebiotic strategies. IMPORTANCE In a healthy colon, the microbiota produces a vast amount of metabolites that are essential to maintaining homeostasis in the colon microenvironment. In fact, these metabolites produced by the microbiota have been linked to diseases such as obesity, cardiovascular disease, and colorectal cancer. In this study, we used healthy nonhuman primate models to investigate the relationship between microbiota and tissue metabolites. We found that both microbiota and metabolites have location-specific signatures along the intestine. Most importantly, we found that metabolites from food sources correlate with multiple bacteria in different intestinal locations. Overall, this work presents a systems-level map of the association between the microbiota and the metabolites in healthy nonhuman primates, provides candidates for experimental validation, and suggests a possibility to regulate the gut microbiota through specific prebiotic combinations.
format	article
author	Ce Yuan Melanie Graham Christopher Staley Subbaya Subramanian
author_facet	Ce Yuan Melanie Graham Christopher Staley Subbaya Subramanian
author_sort	Ce Yuan
title	Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
title_short	Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
title_full	Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
title_fullStr	Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
title_full_unstemmed	Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship
title_sort	mucosal microbiota and metabolome along the intestinal tract reveal a location-specific relationship
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/dc3af3965e0247e89a243c91c076acaf
work_keys_str_mv	AT ceyuan mucosalmicrobiotaandmetabolomealongtheintestinaltractrevealalocationspecificrelationship AT melaniegraham mucosalmicrobiotaandmetabolomealongtheintestinaltractrevealalocationspecificrelationship AT christopherstaley mucosalmicrobiotaandmetabolomealongtheintestinaltractrevealalocationspecificrelationship AT subbayasubramanian mucosalmicrobiotaandmetabolomealongtheintestinaltractrevealalocationspecificrelationship
_version_	1718377770967367680

Mucosal Microbiota and Metabolome along the Intestinal Tract Reveal a Location-Specific Relationship

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