Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy

Rajendra Prakash Maurya,1 Manish Kumar Prajapat,2 Virendra Pratap Singh,1 Meghna Roy,1 Ravina Todi,1 Sanjay Bosak,1 Sunit Kumar Singh,3 Sunil Chaudhary,4 Anil Kumar,5 Sunil R Morekar6 1Regional Institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Prade...

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Autores principales:	Maurya RP, Prajapat MK, Singh VP, Roy M, Todi R, Bosak S, Singh SK, Chaudhary S, Kumar A, Morekar SR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	malondialdehyde chemotherapy malignancy oxidative stress biomarker Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/dc3b4742675d4523a941899ab9412b0c
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spelling	oai:doaj.org-article:dc3b4742675d4523a941899ab9412b0c2021-12-02T10:35:45ZSerum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy1177-5483https://doaj.org/article/dc3b4742675d4523a941899ab9412b0c2021-02-01T00:00:00Zhttps://www.dovepress.com/serum-malondialdehyde-as-a-biomarker-of-oxidative-stress-in-patients-w-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Rajendra Prakash Maurya,1 Manish Kumar Prajapat,2 Virendra Pratap Singh,1 Meghna Roy,1 Ravina Todi,1 Sanjay Bosak,1 Sunit Kumar Singh,3 Sunil Chaudhary,4 Anil Kumar,5 Sunil R Morekar6 1Regional Institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 2Mahamaya Rajkiya Allopathic Medical College, Ambedkar Nagar, UP, India; 3Department of Molecular Biology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 4Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 5Department of Statistics, Faculty of Science & Technology, Mahatma Gandhi Kashi Vidyapith, Varanasi, Uttar Pradesh, India; 6Apollo Specialty Hospital, Navi Mumbai, IndiaCorrespondence: Rajendra Prakash Maurya Email mauryarp_bhu@yahoo.comPurpose: To study the level of serum malondialdehyde (MDA), a biomarker of oxidative stress before and after chemotherapy in various ocular malignancies and to correlate its significance with clinicopathological parameters.Methods: Thirty two histopathologically confirmed cases of primary ocular malignancies were included in this longitudinal cohort study. Detailed clinicopathological assessment was done. Analysis of serum MDA level in the patient before and after chemotherapy was measured and its prognostic significance was analyzed.Results: Maximum cases were of eyelid malignancy (n=18, 56.2%) followed by retinoblastoma (18.8%) and OSSN (6, 18.8%). About 43.75% patients were in the advanced-stage. The tumor was histopathologically well-differentiated in 20 (62.5%) cases. Most common malignancy was sebaceous gland carcinoma of the eyelid (n=10,31.25%). Serum MDA level in patients were significantly higher than controls [5.5712± 0.32779 vs 2.5531± 0.08056 nmol/mL, p< 0.001]. Level was significantly reduced after chemotherapy (4.5146± 0.23209 nmol/mL). Serum MDA was maximum in cases of rhabdomyosarcoma (5.9450± 0.23335 nmol/mL) and retinoblastoma (5.7433± 0.14334 nmol/mL). It was minimum in basal cell carcinoma (5.3775± 0.17746 nmol/mL). Pre chemotherapy serum MDA level was significantly higher in patients having larger tumor (> 20mm, p< 0.001) and having lymph node metastasis than those without lymph node metastasis [5.8350± 0.17113 vs 5.4833± 0.32193 nmol/mL, p< 0.006]. No significant difference was observed in post chemotherapy serum MDA level as for as size of tumor (p=0.947) and histopathological differentiation (p=0.109) was concerned.Conclusion: The serum MDA level is a potential biomarker in primary ocular carcinoma to assess oxidative stress and its impact on response to chemotherapy.Keywords: malondialdehyde, chemotherapy, malignancy, oxidative stress, biomarkerMaurya RPPrajapat MKSingh VPRoy MTodi RBosak SSingh SKChaudhary SKumar AMorekar SRDove Medical Pressarticlemalondialdehydechemotherapymalignancyoxidative stressbiomarkerOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 871-879 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malondialdehyde chemotherapy malignancy oxidative stress biomarker Ophthalmology RE1-994
spellingShingle	malondialdehyde chemotherapy malignancy oxidative stress biomarker Ophthalmology RE1-994 Maurya RP Prajapat MK Singh VP Roy M Todi R Bosak S Singh SK Chaudhary S Kumar A Morekar SR Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
description	Rajendra Prakash Maurya,1 Manish Kumar Prajapat,2 Virendra Pratap Singh,1 Meghna Roy,1 Ravina Todi,1 Sanjay Bosak,1 Sunit Kumar Singh,3 Sunil Chaudhary,4 Anil Kumar,5 Sunil R Morekar6 1Regional Institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 2Mahamaya Rajkiya Allopathic Medical College, Ambedkar Nagar, UP, India; 3Department of Molecular Biology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 4Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 5Department of Statistics, Faculty of Science & Technology, Mahatma Gandhi Kashi Vidyapith, Varanasi, Uttar Pradesh, India; 6Apollo Specialty Hospital, Navi Mumbai, IndiaCorrespondence: Rajendra Prakash Maurya Email mauryarp_bhu@yahoo.comPurpose: To study the level of serum malondialdehyde (MDA), a biomarker of oxidative stress before and after chemotherapy in various ocular malignancies and to correlate its significance with clinicopathological parameters.Methods: Thirty two histopathologically confirmed cases of primary ocular malignancies were included in this longitudinal cohort study. Detailed clinicopathological assessment was done. Analysis of serum MDA level in the patient before and after chemotherapy was measured and its prognostic significance was analyzed.Results: Maximum cases were of eyelid malignancy (n=18, 56.2%) followed by retinoblastoma (18.8%) and OSSN (6, 18.8%). About 43.75% patients were in the advanced-stage. The tumor was histopathologically well-differentiated in 20 (62.5%) cases. Most common malignancy was sebaceous gland carcinoma of the eyelid (n=10,31.25%). Serum MDA level in patients were significantly higher than controls [5.5712± 0.32779 vs 2.5531± 0.08056 nmol/mL, p< 0.001]. Level was significantly reduced after chemotherapy (4.5146± 0.23209 nmol/mL). Serum MDA was maximum in cases of rhabdomyosarcoma (5.9450± 0.23335 nmol/mL) and retinoblastoma (5.7433± 0.14334 nmol/mL). It was minimum in basal cell carcinoma (5.3775± 0.17746 nmol/mL). Pre chemotherapy serum MDA level was significantly higher in patients having larger tumor (> 20mm, p< 0.001) and having lymph node metastasis than those without lymph node metastasis [5.8350± 0.17113 vs 5.4833± 0.32193 nmol/mL, p< 0.006]. No significant difference was observed in post chemotherapy serum MDA level as for as size of tumor (p=0.947) and histopathological differentiation (p=0.109) was concerned.Conclusion: The serum MDA level is a potential biomarker in primary ocular carcinoma to assess oxidative stress and its impact on response to chemotherapy.Keywords: malondialdehyde, chemotherapy, malignancy, oxidative stress, biomarker
format	article
author	Maurya RP Prajapat MK Singh VP Roy M Todi R Bosak S Singh SK Chaudhary S Kumar A Morekar SR
author_facet	Maurya RP Prajapat MK Singh VP Roy M Todi R Bosak S Singh SK Chaudhary S Kumar A Morekar SR
author_sort	Maurya RP
title	Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
title_short	Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
title_full	Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
title_fullStr	Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
title_full_unstemmed	Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy
title_sort	serum malondialdehyde as a biomarker of oxidative stress in patients with primary ocular carcinoma: impact on response to chemotherapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dc3b4742675d4523a941899ab9412b0c
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Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy

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