Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.

We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The uniqu...

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Autores principales:	Erin A Lynch, Morgan G I Langille, Aaron Darling, Elizabeth G Wilbanks, Caitlin Haltiner, Katie S Y Shao, Michael O Starr, Clotilde Teiling, Timothy T Harkins, Robert A Edwards, Jonathan A Eisen, Marc T Facciotti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc3fbd12bad04a398d3678030f3740a7
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spelling	oai:doaj.org-article:dc3fbd12bad04a398d3678030f3740a72021-11-18T07:11:22ZSequencing of seven haloarchaeal genomes reveals patterns of genomic flux.1932-620310.1371/journal.pone.0041389https://doaj.org/article/dc3fbd12bad04a398d3678030f3740a72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848480/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The unique physiological properties of these organisms also make them good candidates for novel enzyme discovery for biotechnological applications. Seven genomes were sequenced to ∼20×coverage and assembled to an average of 50 contigs (range 5 scaffolds-168 contigs). Comparisons of protein-coding gene compliments revealed large-scale differences in COG functional group enrichment between these genera. Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. Insights gained from this study emphasize the importance of haloarchaea for investigation of archaeal biology.Erin A LynchMorgan G I LangilleAaron DarlingElizabeth G WilbanksCaitlin HaltinerKatie S Y ShaoMichael O StarrClotilde TeilingTimothy T HarkinsRobert A EdwardsJonathan A EisenMarc T FacciottiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41389 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erin A Lynch Morgan G I Langille Aaron Darling Elizabeth G Wilbanks Caitlin Haltiner Katie S Y Shao Michael O Starr Clotilde Teiling Timothy T Harkins Robert A Edwards Jonathan A Eisen Marc T Facciotti Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
description	We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The unique physiological properties of these organisms also make them good candidates for novel enzyme discovery for biotechnological applications. Seven genomes were sequenced to ∼20×coverage and assembled to an average of 50 contigs (range 5 scaffolds-168 contigs). Comparisons of protein-coding gene compliments revealed large-scale differences in COG functional group enrichment between these genera. Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. Insights gained from this study emphasize the importance of haloarchaea for investigation of archaeal biology.
format	article
author	Erin A Lynch Morgan G I Langille Aaron Darling Elizabeth G Wilbanks Caitlin Haltiner Katie S Y Shao Michael O Starr Clotilde Teiling Timothy T Harkins Robert A Edwards Jonathan A Eisen Marc T Facciotti
author_facet	Erin A Lynch Morgan G I Langille Aaron Darling Elizabeth G Wilbanks Caitlin Haltiner Katie S Y Shao Michael O Starr Clotilde Teiling Timothy T Harkins Robert A Edwards Jonathan A Eisen Marc T Facciotti
author_sort	Erin A Lynch
title	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
title_short	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
title_full	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
title_fullStr	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
title_full_unstemmed	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
title_sort	sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/dc3fbd12bad04a398d3678030f3740a7
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Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.

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