Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018

Abstract Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa has seen an increase in the frequency of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Republic of Congo (DRC) and the Ce...

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Autores principales:	Nicolas Berthet, Stéphane Descorps-Declère, Camille Besombes, Manon Curaudeau, Andriniaina Andy Nkili Meyong, Benjamin Selekon, Ingrid Labouba, Ella Cyrielle Gonofio, Rita Sem Ouilibona, Huguette Dorine Simo Tchetgna, Maxence Feher, Arnaud Fontanet, Mirdad Kazanji, Jean-Claude Manuguerra, Alexandre Hassanin, Antoine Gessain, Emmanuel Nakoune
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc4091e70d8c4de1bd01435926639f56
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spelling	oai:doaj.org-article:dc4091e70d8c4de1bd01435926639f562021-12-02T18:02:43ZGenomic history of human monkey pox infections in the Central African Republic between 2001 and 201810.1038/s41598-021-92315-82045-2322https://doaj.org/article/dc4091e70d8c4de1bd01435926639f562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92315-8https://doaj.org/toc/2045-2322Abstract Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa has seen an increase in the frequency of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Republic of Congo (DRC) and the Central African Republic (CAR). To date, no complete MPXV viral genome has been published from the human cases identified in the CAR. The objective of this study was to sequence the full genome of 10 MPXV isolates collected during the CAR epidemics between 2001 and 2018 in order to determine their phylogenetic relationships among MPXV lineages previously described in Central Africa and West Africa. Our phylogenetic results indicate that the 10 CAR isolates belong to three lineages closely related to those found in DRC. The phylogenetic pattern shows that all of them emerged in the rainforest block of the Congo Basin. Since most human index cases in CAR occurred at the northern edge of western and eastern rainforests, transmissions from wild animals living in the rainforest is the most probable hypothesis. In addition, molecular dating estimates suggest that periods of intense political instability resulting in population movements within the country often associated also with increased poverty may have led to more frequent contact with host wild animals. The CAR socio-economic situation, armed conflicts and ecological disturbances will likely incite populations to interact more and more with wild animals and thus increase the risk of zoonotic spillover.Nicolas BerthetStéphane Descorps-DeclèreCamille BesombesManon CuraudeauAndriniaina Andy Nkili MeyongBenjamin SelekonIngrid LaboubaElla Cyrielle GonofioRita Sem OuilibonaHuguette Dorine Simo TchetgnaMaxence FeherArnaud FontanetMirdad KazanjiJean-Claude ManuguerraAlexandre HassaninAntoine GessainEmmanuel NakouneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicolas Berthet Stéphane Descorps-Declère Camille Besombes Manon Curaudeau Andriniaina Andy Nkili Meyong Benjamin Selekon Ingrid Labouba Ella Cyrielle Gonofio Rita Sem Ouilibona Huguette Dorine Simo Tchetgna Maxence Feher Arnaud Fontanet Mirdad Kazanji Jean-Claude Manuguerra Alexandre Hassanin Antoine Gessain Emmanuel Nakoune Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
description	Abstract Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa has seen an increase in the frequency of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Republic of Congo (DRC) and the Central African Republic (CAR). To date, no complete MPXV viral genome has been published from the human cases identified in the CAR. The objective of this study was to sequence the full genome of 10 MPXV isolates collected during the CAR epidemics between 2001 and 2018 in order to determine their phylogenetic relationships among MPXV lineages previously described in Central Africa and West Africa. Our phylogenetic results indicate that the 10 CAR isolates belong to three lineages closely related to those found in DRC. The phylogenetic pattern shows that all of them emerged in the rainforest block of the Congo Basin. Since most human index cases in CAR occurred at the northern edge of western and eastern rainforests, transmissions from wild animals living in the rainforest is the most probable hypothesis. In addition, molecular dating estimates suggest that periods of intense political instability resulting in population movements within the country often associated also with increased poverty may have led to more frequent contact with host wild animals. The CAR socio-economic situation, armed conflicts and ecological disturbances will likely incite populations to interact more and more with wild animals and thus increase the risk of zoonotic spillover.
format	article
author	Nicolas Berthet Stéphane Descorps-Declère Camille Besombes Manon Curaudeau Andriniaina Andy Nkili Meyong Benjamin Selekon Ingrid Labouba Ella Cyrielle Gonofio Rita Sem Ouilibona Huguette Dorine Simo Tchetgna Maxence Feher Arnaud Fontanet Mirdad Kazanji Jean-Claude Manuguerra Alexandre Hassanin Antoine Gessain Emmanuel Nakoune
author_facet	Nicolas Berthet Stéphane Descorps-Declère Camille Besombes Manon Curaudeau Andriniaina Andy Nkili Meyong Benjamin Selekon Ingrid Labouba Ella Cyrielle Gonofio Rita Sem Ouilibona Huguette Dorine Simo Tchetgna Maxence Feher Arnaud Fontanet Mirdad Kazanji Jean-Claude Manuguerra Alexandre Hassanin Antoine Gessain Emmanuel Nakoune
author_sort	Nicolas Berthet
title	Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
title_short	Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
title_full	Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
title_fullStr	Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
title_full_unstemmed	Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
title_sort	genomic history of human monkey pox infections in the central african republic between 2001 and 2018
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc4091e70d8c4de1bd01435926639f56
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Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018

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