The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development
BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode.
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Nature Portfolio
2018
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oai:doaj.org-article:dc40f4f13882471db57366dceeae73872021-12-02T15:33:45ZThe MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development10.1038/s41467-018-03576-32041-1723https://doaj.org/article/dc40f4f13882471db57366dceeae73872018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03576-3https://doaj.org/toc/2041-1723BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode.Maria A. SchumacherChris D. den HengstMatthew J. BushT. B. K. LeNgat T. TranGovind ChandraWenjie ZengBrady TravisRichard G. BrennanMark J. ButtnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Maria A. Schumacher Chris D. den Hengst Matthew J. Bush T. B. K. Le Ngat T. Tran Govind Chandra Wenjie Zeng Brady Travis Richard G. Brennan Mark J. Buttner The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| description |
BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode. |
| format |
article |
| author |
Maria A. Schumacher Chris D. den Hengst Matthew J. Bush T. B. K. Le Ngat T. Tran Govind Chandra Wenjie Zeng Brady Travis Richard G. Brennan Mark J. Buttner |
| author_facet |
Maria A. Schumacher Chris D. den Hengst Matthew J. Bush T. B. K. Le Ngat T. Tran Govind Chandra Wenjie Zeng Brady Travis Richard G. Brennan Mark J. Buttner |
| author_sort |
Maria A. Schumacher |
| title |
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| title_short |
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| title_full |
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| title_fullStr |
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| title_full_unstemmed |
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development |
| title_sort |
merr-like protein bldc binds dna direct repeats as cooperative multimers to regulate streptomyces development |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/dc40f4f13882471db57366dceeae7387 |
| work_keys_str_mv |
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| _version_ |
1718387054838022144 |