The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development

BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode.

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Bibliographic Details
Main Authors: Maria A. Schumacher, Chris D. den Hengst, Matthew J. Bush, T. B. K. Le, Ngat T. Tran, Govind Chandra, Wenjie Zeng, Brady Travis, Richard G. Brennan, Mark J. Buttner
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/dc40f4f13882471db57366dceeae7387
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