Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
Luoning Gou,1,* Ming Xiang,2,* Xiao Ran,3,* Fen Wang,1 Shujun Zhang,1 Shusheng Li,3 Kun Dong,1 Xi Chen,1 Yangxin Huang,4 Chengzhen Meng,2 Qian Fan,2 Yan Yang,1 Xuefeng Yu,1 Delin Ma,1 Ping Yin2 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and...
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Dove Medical Press
2021
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oai:doaj.org-article:dc41b3f61c7743fcb85d47802de180222021-12-02T10:41:26ZHyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study1178-7007https://doaj.org/article/dc41b3f61c7743fcb85d47802de180222021-01-01T00:00:00Zhttps://www.dovepress.com/hyperosmolarity-deserves-more-attention-in-critically-ill-covid-19-pat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Luoning Gou,1,* Ming Xiang,2,* Xiao Ran,3,* Fen Wang,1 Shujun Zhang,1 Shusheng Li,3 Kun Dong,1 Xi Chen,1 Yangxin Huang,4 Chengzhen Meng,2 Qian Fan,2 Yan Yang,1 Xuefeng Yu,1 Delin Ma,1 Ping Yin2 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4College of Public Health, University of South Florida, Tampa, Florida, The United States*These authors contributed equally to this workCorrespondence: Ping Yin; Delin MaTongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Road, Wuhan, 430030 Hubei, People’s Republic of ChinaTel + 86-27-83692832Fax +86-27-83692333Email pingyin2000@126.comDelin Ma Email maderine4@163.comPurpose: Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be evaluated.Methods: We included adult patients confirmed with SARS-CoV-2 infection who were critically ill and admitted to the intensive care unit (ICU) of Tongji Hospital in Wuhan from Feb 4, 2020 to Feb 20, 2020. Data were collected and compared between patients who died and improved. Logistic regression was used to explore the risk factors for death of SARS-CoV-2-infected critically ill patients.Results: A total of 160 critically ill patients with SARS-CoV-2 infection were included, of which 146 patients with appeared outcomes were included into the final analysis. The random blood glucose, serum sodium and effective plasma osmolarity were higher in deceased patients, especially in patients with diabetes. There were 7 patients with diabetes with hyperosmolar status and all of them were deceased. Multivariable regression revealed that older age (odds ratio 4.28, 95% CI 1.01– 18.20; p = 0.049), higher C-reactive protein (odds ratio 1.01, 1.00– 1.03; p = 0.024), higher interleukin-6 (odds ratio 1.01, 1.00– 1.03; p = 0.0323), and d-dimer greater than 1 μg/mL (odds ratio 1.10, 1.01– 1.20; p = 0.032) at admission were associated with increased odds of death.Conclusion: In conclusion, hyperosmolarity needs more attention and may contribute to mortality in critically ill patients with COVID-19, especially in those with diabetes. Older age, inflammatory response, and thrombosis may be risk factors for death of critically ill patients with SARS-CoV-2 infection.Keywords: SARS-CoV-2, critically ill, hyperosmolarity, diabetes, risk factors, mortalityGou LXiang MRan XWang FZhang SLi SDong KChen XHuang YMeng CFan QYang YYu XMa DYin PDove Medical Pressarticlesars-cov-2critically illhyperosmolaritydiabetesrisk factorsmortalitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 47-58 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
sars-cov-2 critically ill hyperosmolarity diabetes risk factors mortality Specialties of internal medicine RC581-951 |
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sars-cov-2 critically ill hyperosmolarity diabetes risk factors mortality Specialties of internal medicine RC581-951 Gou L Xiang M Ran X Wang F Zhang S Li S Dong K Chen X Huang Y Meng C Fan Q Yang Y Yu X Ma D Yin P Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| description |
Luoning Gou,1,* Ming Xiang,2,* Xiao Ran,3,* Fen Wang,1 Shujun Zhang,1 Shusheng Li,3 Kun Dong,1 Xi Chen,1 Yangxin Huang,4 Chengzhen Meng,2 Qian Fan,2 Yan Yang,1 Xuefeng Yu,1 Delin Ma,1 Ping Yin2 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4College of Public Health, University of South Florida, Tampa, Florida, The United States*These authors contributed equally to this workCorrespondence: Ping Yin; Delin MaTongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Road, Wuhan, 430030 Hubei, People’s Republic of ChinaTel + 86-27-83692832Fax +86-27-83692333Email pingyin2000@126.comDelin Ma Email maderine4@163.comPurpose: Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be evaluated.Methods: We included adult patients confirmed with SARS-CoV-2 infection who were critically ill and admitted to the intensive care unit (ICU) of Tongji Hospital in Wuhan from Feb 4, 2020 to Feb 20, 2020. Data were collected and compared between patients who died and improved. Logistic regression was used to explore the risk factors for death of SARS-CoV-2-infected critically ill patients.Results: A total of 160 critically ill patients with SARS-CoV-2 infection were included, of which 146 patients with appeared outcomes were included into the final analysis. The random blood glucose, serum sodium and effective plasma osmolarity were higher in deceased patients, especially in patients with diabetes. There were 7 patients with diabetes with hyperosmolar status and all of them were deceased. Multivariable regression revealed that older age (odds ratio 4.28, 95% CI 1.01– 18.20; p = 0.049), higher C-reactive protein (odds ratio 1.01, 1.00– 1.03; p = 0.024), higher interleukin-6 (odds ratio 1.01, 1.00– 1.03; p = 0.0323), and d-dimer greater than 1 μg/mL (odds ratio 1.10, 1.01– 1.20; p = 0.032) at admission were associated with increased odds of death.Conclusion: In conclusion, hyperosmolarity needs more attention and may contribute to mortality in critically ill patients with COVID-19, especially in those with diabetes. Older age, inflammatory response, and thrombosis may be risk factors for death of critically ill patients with SARS-CoV-2 infection.Keywords: SARS-CoV-2, critically ill, hyperosmolarity, diabetes, risk factors, mortality |
| format |
article |
| author |
Gou L Xiang M Ran X Wang F Zhang S Li S Dong K Chen X Huang Y Meng C Fan Q Yang Y Yu X Ma D Yin P |
| author_facet |
Gou L Xiang M Ran X Wang F Zhang S Li S Dong K Chen X Huang Y Meng C Fan Q Yang Y Yu X Ma D Yin P |
| author_sort |
Gou L |
| title |
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| title_short |
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| title_full |
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| title_fullStr |
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| title_full_unstemmed |
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study |
| title_sort |
hyperosmolarity deserves more attention in critically ill covid-19 patients with diabetes: a cohort-based study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/dc41b3f61c7743fcb85d47802de18022 |
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