Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.

<h4>Rationale</h4>Epicardial Adipose Tissue (EAT) volume as determined by chest computed tomography (CT) is an independent marker of cardiovascular events in the general population. COPD patients have an increased risk of cardiovascular disease, however nothing is known about the EAT vol...

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Autores principales:	Jorge Zagaceta, Javier J Zulueta, Gorka Bastarrika, Inmaculada Colina, Ana B Alcaide, Arantza Campo, Bartolome R Celli, Juan P de Torres
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc421c082b8743258bdb5ce358e12739
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spelling	oai:doaj.org-article:dc421c082b8743258bdb5ce358e127392021-11-18T07:42:45ZEpicardial adipose tissue in patients with chronic obstructive pulmonary disease.1932-620310.1371/journal.pone.0065593https://doaj.org/article/dc421c082b8743258bdb5ce358e127392013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762399/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Epicardial Adipose Tissue (EAT) volume as determined by chest computed tomography (CT) is an independent marker of cardiovascular events in the general population. COPD patients have an increased risk of cardiovascular disease, however nothing is known about the EAT volume in this population.<h4>Objectives</h4>To assess EAT volume in COPD and explore its association with clinical and physiological variables of disease severity.<h4>Methods</h4>We measured EAT using low-dose CT in 171 stable COPD patients and 70 controls matched by age, smoking history and BMI. We determined blood pressure, cholesterol, glucose and HbA1c levels, microalbuminuria, lung function, BODE index, co-morbidity index and coronary artery calcium score (CAC). EAT volume were compared between groups. Uni and multivariate analyses explored the relationship between EAT volume and the COPD related variables.<h4>Results</h4>COPD patients had a higher EAT volume [143.7 (P25-75, 108.3-196.6) vs 129.1 (P25-75, 91.3-170.8) cm(3), p = 0.02)] and the EAT volume was significantly associated with CAC (r = 0.38, p<0.001) and CRP (r = 0.32, p<0.001) but not with microalbuminuria (r = 0.12, p = 0.13). In COPD patients, EAT volume was associated with: age, pack-years, BMI, gender, FEV1%, 6 MWD, MMRC and HTN. Multivariate analysis showed that only pack-years (B = 0.6, 95% CI: 0.5-1.3), BMI (B = 7.8, 95% CI: 5.7-9.9) and 6 MWD (B = -0.2, 95% CI: -0.3--0.1), predicted EAT volume.<h4>Conclusions</h4>EAT volume is increased in COPD patients and is independently associated with smoking history, BMI and exercise capacity, all modifiable risk factors of future cardiovascular events. EAT volume could be a non-invasive marker of COPD patients at high risk for future cardiovascular events.Jorge ZagacetaJavier J ZuluetaGorka BastarrikaInmaculada ColinaAna B AlcaideArantza CampoBartolome R CelliJuan P de TorresPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65593 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Zagaceta Javier J Zulueta Gorka Bastarrika Inmaculada Colina Ana B Alcaide Arantza Campo Bartolome R Celli Juan P de Torres Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
description	<h4>Rationale</h4>Epicardial Adipose Tissue (EAT) volume as determined by chest computed tomography (CT) is an independent marker of cardiovascular events in the general population. COPD patients have an increased risk of cardiovascular disease, however nothing is known about the EAT volume in this population.<h4>Objectives</h4>To assess EAT volume in COPD and explore its association with clinical and physiological variables of disease severity.<h4>Methods</h4>We measured EAT using low-dose CT in 171 stable COPD patients and 70 controls matched by age, smoking history and BMI. We determined blood pressure, cholesterol, glucose and HbA1c levels, microalbuminuria, lung function, BODE index, co-morbidity index and coronary artery calcium score (CAC). EAT volume were compared between groups. Uni and multivariate analyses explored the relationship between EAT volume and the COPD related variables.<h4>Results</h4>COPD patients had a higher EAT volume [143.7 (P25-75, 108.3-196.6) vs 129.1 (P25-75, 91.3-170.8) cm(3), p = 0.02)] and the EAT volume was significantly associated with CAC (r = 0.38, p<0.001) and CRP (r = 0.32, p<0.001) but not with microalbuminuria (r = 0.12, p = 0.13). In COPD patients, EAT volume was associated with: age, pack-years, BMI, gender, FEV1%, 6 MWD, MMRC and HTN. Multivariate analysis showed that only pack-years (B = 0.6, 95% CI: 0.5-1.3), BMI (B = 7.8, 95% CI: 5.7-9.9) and 6 MWD (B = -0.2, 95% CI: -0.3--0.1), predicted EAT volume.<h4>Conclusions</h4>EAT volume is increased in COPD patients and is independently associated with smoking history, BMI and exercise capacity, all modifiable risk factors of future cardiovascular events. EAT volume could be a non-invasive marker of COPD patients at high risk for future cardiovascular events.
format	article
author	Jorge Zagaceta Javier J Zulueta Gorka Bastarrika Inmaculada Colina Ana B Alcaide Arantza Campo Bartolome R Celli Juan P de Torres
author_facet	Jorge Zagaceta Javier J Zulueta Gorka Bastarrika Inmaculada Colina Ana B Alcaide Arantza Campo Bartolome R Celli Juan P de Torres
author_sort	Jorge Zagaceta
title	Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
title_short	Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
title_full	Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
title_fullStr	Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
title_full_unstemmed	Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
title_sort	epicardial adipose tissue in patients with chronic obstructive pulmonary disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/dc421c082b8743258bdb5ce358e12739
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Epicardial adipose tissue in patients with chronic obstructive pulmonary disease.

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