Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer

We report the case of a 64-year-old man with advanced small-cell lung cancer who developed fulminant amoebic colitis during cytotoxic chemotherapy. During the first cycle of carboplatin/etoposide treatment, febrile neutropenia and grade 4 neutropenia developed. Because diarrhea, abdominal pain, and...

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Autores principales:	Aya Kitaoka, Kazuya Tanimura, Yuto Yasuda, Kensuke Nishioka, Yutaka Hirayama, Kiyoshi Uemasu, Daisuke Iwashima, Sou Arita, Toshiyuki Kitai, Susumu Hoshi, Emi Date, Norishige Iizuka, Ken-ichi Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Entamoeba histolytica Fulminant amebic colitis Activation Chemotherapy Small-cell lung cancer Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/dc440a34809c48368a23a348d348c76f
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spelling	oai:doaj.org-article:dc440a34809c48368a23a348d348c76f2021-11-20T05:06:15ZSuccessful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer2214-250910.1016/j.idcr.2021.e01337https://doaj.org/article/dc440a34809c48368a23a348d348c76f2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214250921002936https://doaj.org/toc/2214-2509We report the case of a 64-year-old man with advanced small-cell lung cancer who developed fulminant amoebic colitis during cytotoxic chemotherapy. During the first cycle of carboplatin/etoposide treatment, febrile neutropenia and grade 4 neutropenia developed. Because diarrhea, abdominal pain, and bloody stool were observed, abdominal computed tomography was performed, showing intussusception, and extensive colectomy and colostomy were performed. Histopathology of the colon revealed gastrointestinal necrosis and perforation due to Entamoeba histolytica infection. Amoebiasis improved after treatment with metronidazole and paromomycin. The second cycle of carboplatin/etoposide with dose reduction was completed, resulting in a partial response to small-cell lung cancer.The results of this case suggest that paromomycin is an additional option for amoebiasis during cytotoxic chemotherapy, and persistent diarrhea during cytotoxic chemotherapy should alert clinicians to consider the development of amoebiasis.Aya KitaokaKazuya TanimuraYuto YasudaKensuke NishiokaYutaka HirayamaKiyoshi UemasuDaisuke IwashimaSou AritaToshiyuki KitaiSusumu HoshiEmi DateNorishige IizukaKen-ichi TakahashiElsevierarticleEntamoeba histolyticaFulminant amebic colitisActivationChemotherapySmall-cell lung cancerInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01337- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Entamoeba histolytica Fulminant amebic colitis Activation Chemotherapy Small-cell lung cancer Infectious and parasitic diseases RC109-216
spellingShingle	Entamoeba histolytica Fulminant amebic colitis Activation Chemotherapy Small-cell lung cancer Infectious and parasitic diseases RC109-216 Aya Kitaoka Kazuya Tanimura Yuto Yasuda Kensuke Nishioka Yutaka Hirayama Kiyoshi Uemasu Daisuke Iwashima Sou Arita Toshiyuki Kitai Susumu Hoshi Emi Date Norishige Iizuka Ken-ichi Takahashi Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
description	We report the case of a 64-year-old man with advanced small-cell lung cancer who developed fulminant amoebic colitis during cytotoxic chemotherapy. During the first cycle of carboplatin/etoposide treatment, febrile neutropenia and grade 4 neutropenia developed. Because diarrhea, abdominal pain, and bloody stool were observed, abdominal computed tomography was performed, showing intussusception, and extensive colectomy and colostomy were performed. Histopathology of the colon revealed gastrointestinal necrosis and perforation due to Entamoeba histolytica infection. Amoebiasis improved after treatment with metronidazole and paromomycin. The second cycle of carboplatin/etoposide with dose reduction was completed, resulting in a partial response to small-cell lung cancer.The results of this case suggest that paromomycin is an additional option for amoebiasis during cytotoxic chemotherapy, and persistent diarrhea during cytotoxic chemotherapy should alert clinicians to consider the development of amoebiasis.
format	article
author	Aya Kitaoka Kazuya Tanimura Yuto Yasuda Kensuke Nishioka Yutaka Hirayama Kiyoshi Uemasu Daisuke Iwashima Sou Arita Toshiyuki Kitai Susumu Hoshi Emi Date Norishige Iizuka Ken-ichi Takahashi
author_facet	Aya Kitaoka Kazuya Tanimura Yuto Yasuda Kensuke Nishioka Yutaka Hirayama Kiyoshi Uemasu Daisuke Iwashima Sou Arita Toshiyuki Kitai Susumu Hoshi Emi Date Norishige Iizuka Ken-ichi Takahashi
author_sort	Aya Kitaoka
title	Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
title_short	Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
title_full	Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
title_fullStr	Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
title_full_unstemmed	Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
title_sort	successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dc440a34809c48368a23a348d348c76f
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Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer

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