Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm
Juwan Park1, Michael S Lee2, Andrew R Harrison31Department of Ophthalmology, The Catholic University of Korea, Seoul, Korea; 2Department of Ophthalmology, Neurology and Neurosurgery, 3Department of Ophthalmology and Otolaryngology, University of Minnesota, MN, USAAbstract: Even though conventional b...
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Dove Medical Press
2011
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oai:doaj.org-article:dc46dfaebe1046dda2310de72c92e40d2021-12-02T08:41:06ZProfile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm1177-54671177-5483https://doaj.org/article/dc46dfaebe1046dda2310de72c92e40d2011-06-01T00:00:00Zhttp://www.dovepress.com/profile-of-xeominreg-incobotulinumtoxina-for-the-treatment-of-blepharo-a7573https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Juwan Park1, Michael S Lee2, Andrew R Harrison31Department of Ophthalmology, The Catholic University of Korea, Seoul, Korea; 2Department of Ophthalmology, Neurology and Neurosurgery, 3Department of Ophthalmology and Otolaryngology, University of Minnesota, MN, USAAbstract: Even though conventional botulinum neurotoxin (BoNT) products have shown successful treatment results in patients with benign blepharospasm (BEB), the main, potential long-term side effect of BoNT use is the development of immunologic resistance due to the production of neutralizing antibody to the neurotoxin after repeated injections. Xeomin® (incobotulinumtoxinA), a unique botulinum neurotoxin type A (BoNT/A) drug free of complexing proteins otherwise contained in all conventional BoNT/A drugs, was recently approved by US Food and Drug Administration for the treatment of cervical dystonia or blepharospasm in adults. The newly approved BoNT/A drug may overcome this limitation of previous conventional products, since it contains pure neurotoxin (150 kDa) through a manufacturing process that separates it from complexing proteins such as hemagglutinins produced by fermentation of Clostridium botulinum. Many studies have also shown that Xeomin® has the same efficacy and safety profile as complexing protein-containing products such as Botox® and is exchangeable with Botox® using a simple 1:1 conversion ratio. Xeomin® represents a new treatment option for the repeated treatment of patients with blepharospasm in that it may reduce antibody-induced therapy failure. But, long-term comparative trials in naïve patients between Xeomin® and conventional BoNT/A drugs are required to confirm the low immunogenicity of Xeomin®.Keywords: blepharospasm, botulinum neurotoxin type A, Xeomin®, incobotulinumtoxinA, complexing proteins, neutralizing antibodiesPark JLee MSHarrison ARDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 725-732 (2011) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Park J Lee MS Harrison AR Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
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Juwan Park1, Michael S Lee2, Andrew R Harrison31Department of Ophthalmology, The Catholic University of Korea, Seoul, Korea; 2Department of Ophthalmology, Neurology and Neurosurgery, 3Department of Ophthalmology and Otolaryngology, University of Minnesota, MN, USAAbstract: Even though conventional botulinum neurotoxin (BoNT) products have shown successful treatment results in patients with benign blepharospasm (BEB), the main, potential long-term side effect of BoNT use is the development of immunologic resistance due to the production of neutralizing antibody to the neurotoxin after repeated injections. Xeomin® (incobotulinumtoxinA), a unique botulinum neurotoxin type A (BoNT/A) drug free of complexing proteins otherwise contained in all conventional BoNT/A drugs, was recently approved by US Food and Drug Administration for the treatment of cervical dystonia or blepharospasm in adults. The newly approved BoNT/A drug may overcome this limitation of previous conventional products, since it contains pure neurotoxin (150 kDa) through a manufacturing process that separates it from complexing proteins such as hemagglutinins produced by fermentation of Clostridium botulinum. Many studies have also shown that Xeomin® has the same efficacy and safety profile as complexing protein-containing products such as Botox® and is exchangeable with Botox® using a simple 1:1 conversion ratio. Xeomin® represents a new treatment option for the repeated treatment of patients with blepharospasm in that it may reduce antibody-induced therapy failure. But, long-term comparative trials in naïve patients between Xeomin® and conventional BoNT/A drugs are required to confirm the low immunogenicity of Xeomin®.Keywords: blepharospasm, botulinum neurotoxin type A, Xeomin®, incobotulinumtoxinA, complexing proteins, neutralizing antibodies |
| format |
article |
| author |
Park J Lee MS Harrison AR |
| author_facet |
Park J Lee MS Harrison AR |
| author_sort |
Park J |
| title |
Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
| title_short |
Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
| title_full |
Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
| title_fullStr |
Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
| title_full_unstemmed |
Profile of Xeomin® (incobotulinumtoxinA) for the treatment of blepharospasm |
| title_sort |
profile of xeomin® (incobotulinumtoxina) for the treatment of blepharospasm |
| publisher |
Dove Medical Press |
| publishDate |
2011 |
| url |
https://doaj.org/article/dc46dfaebe1046dda2310de72c92e40d |
| work_keys_str_mv |
AT parkj profileofxeominampregincobotulinumtoxinaforthetreatmentofblepharospasm AT leems profileofxeominampregincobotulinumtoxinaforthetreatmentofblepharospasm AT harrisonar profileofxeominampregincobotulinumtoxinaforthetreatmentofblepharospasm |
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