Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at t...

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Autores principales:	Devon C. Crawford, Denise M. O. Ramirez, Brent Trauterman, Lisa M. Monteggia, Ege T. Kavalali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dc471629a1504a31be0f7fd4efcefb46
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spelling	oai:doaj.org-article:dc471629a1504a31be0f7fd4efcefb462021-12-02T14:42:42ZSelective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy10.1038/ncomms144362041-1723https://doaj.org/article/dc471629a1504a31be0f7fd4efcefb462017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14436https://doaj.org/toc/2041-1723Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at the postsynaptic side in cultured neurons and alters synaptic plasticity in acute brain slices.Devon C. CrawfordDenise M. O. RamirezBrent TrautermanLisa M. MonteggiaEge T. KavalaliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Devon C. Crawford Denise M. O. Ramirez Brent Trauterman Lisa M. Monteggia Ege T. Kavalali Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
description	Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at the postsynaptic side in cultured neurons and alters synaptic plasticity in acute brain slices.
format	article
author	Devon C. Crawford Denise M. O. Ramirez Brent Trauterman Lisa M. Monteggia Ege T. Kavalali
author_facet	Devon C. Crawford Denise M. O. Ramirez Brent Trauterman Lisa M. Monteggia Ege T. Kavalali
author_sort	Devon C. Crawford
title	Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_short	Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_full	Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_fullStr	Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_full_unstemmed	Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_sort	selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dc471629a1504a31be0f7fd4efcefb46
work_keys_str_mv	AT devonccrawford selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy AT denisemoramirez selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy AT brenttrauterman selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy AT lisammonteggia selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy AT egetkavalali selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy
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Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

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