Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.

Synapses are particularly prone to dynamic alterations and thus play a major role in neuronal plasticity. Dynamic excitatory synapses are located at the membranous neuronal protrusions called dendritic spines. The ability to change synaptic connections involves both alterations at the morphological...

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Autores principales:	Zsuzsanna Szepesi, Eric Hosy, Blazej Ruszczycki, Monika Bijata, Marta Pyskaty, Arthur Bikbaev, Martin Heine, Daniel Choquet, Leszek Kaczmarek, Jakub Wlodarczyk
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc4744a825bd4ffb92a38ab7ed2c89cc
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spelling	oai:doaj.org-article:dc4744a825bd4ffb92a38ab7ed2c89cc2021-11-18T08:18:16ZSynaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.1932-620310.1371/journal.pone.0098274https://doaj.org/article/dc4744a825bd4ffb92a38ab7ed2c89cc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24853857/?tool=EBIhttps://doaj.org/toc/1932-6203Synapses are particularly prone to dynamic alterations and thus play a major role in neuronal plasticity. Dynamic excitatory synapses are located at the membranous neuronal protrusions called dendritic spines. The ability to change synaptic connections involves both alterations at the morphological level and changes in postsynaptic receptor composition. We report that endogenous matrix metalloproteinase (MMP) activity promotes the structural and functional plasticity of local synapses by its effect on glutamate receptor mobility and content. We used live imaging of cultured hippocampal neurons and quantitative morphological analysis to show that chemical long-term potentiation (cLTP) induces the permanent enlargement of a subset of small dendritic spines in an MMP-dependent manner. We also used a superresolution microscopy approach and found that spine expansion induced by cLTP was accompanied by MMP-dependent immobilization and synaptic accumulation as well as the clustering of GluA1-containing AMPA receptors. Altogether, our results reveal novel molecular and cellular mechanisms of synaptic plasticity.Zsuzsanna SzepesiEric HosyBlazej RuszczyckiMonika BijataMarta PyskatyArthur BikbaevMartin HeineDaniel ChoquetLeszek KaczmarekJakub WlodarczykPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98274 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zsuzsanna Szepesi Eric Hosy Blazej Ruszczycki Monika Bijata Marta Pyskaty Arthur Bikbaev Martin Heine Daniel Choquet Leszek Kaczmarek Jakub Wlodarczyk Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
description	Synapses are particularly prone to dynamic alterations and thus play a major role in neuronal plasticity. Dynamic excitatory synapses are located at the membranous neuronal protrusions called dendritic spines. The ability to change synaptic connections involves both alterations at the morphological level and changes in postsynaptic receptor composition. We report that endogenous matrix metalloproteinase (MMP) activity promotes the structural and functional plasticity of local synapses by its effect on glutamate receptor mobility and content. We used live imaging of cultured hippocampal neurons and quantitative morphological analysis to show that chemical long-term potentiation (cLTP) induces the permanent enlargement of a subset of small dendritic spines in an MMP-dependent manner. We also used a superresolution microscopy approach and found that spine expansion induced by cLTP was accompanied by MMP-dependent immobilization and synaptic accumulation as well as the clustering of GluA1-containing AMPA receptors. Altogether, our results reveal novel molecular and cellular mechanisms of synaptic plasticity.
format	article
author	Zsuzsanna Szepesi Eric Hosy Blazej Ruszczycki Monika Bijata Marta Pyskaty Arthur Bikbaev Martin Heine Daniel Choquet Leszek Kaczmarek Jakub Wlodarczyk
author_facet	Zsuzsanna Szepesi Eric Hosy Blazej Ruszczycki Monika Bijata Marta Pyskaty Arthur Bikbaev Martin Heine Daniel Choquet Leszek Kaczmarek Jakub Wlodarczyk
author_sort	Zsuzsanna Szepesi
title	Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
title_short	Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
title_full	Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
title_fullStr	Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
title_full_unstemmed	Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.
title_sort	synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of glua1-ampa receptors.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/dc4744a825bd4ffb92a38ab7ed2c89cc
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Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors.

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