Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits

Abstract The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbi...

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Autores principales:	Christian J. F. Bertens, Ralph J. S. van Mechelen, Tos T. J. M. Berendschot, Marlies Gijs, Jarno E. J. Wolters, Theo G. M. F. Gorgels, Rudy M. M. A. Nuijts, Henny J. M. Beckers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dc4b4f9e4dab455facc220f13d94f395
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spelling	oai:doaj.org-article:dc4b4f9e4dab455facc220f13d94f3952021-12-02T17:17:40ZRepeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits10.1038/s41598-021-98762-72045-2322https://doaj.org/article/dc4b4f9e4dab455facc220f13d94f3952021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98762-7https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbits with the TonoVet tonometer. Repeatability was determined using the coefficient of variation (CoV) for two observers. For the TonoLab (6.55%) and TonoVet (6.38%) the CoV was lower than for the TonoPEN AVIA (10.88%). The reproducibility was highest for the TonoVet (0.2 ± 3.3 mmHg), followed by the TonoLab (0 ± 12.89 mmHg) and lowest for the TonoPEN AVIA (− 1.48 ± 10.3 mmHg). The TonoLab and TonoVet showed the highest agreement (r = 0.85, R2 = 0.73). After sedation, a significant IOP reduction (often > 25%) was observed. Our results show that among the three tonometers tested, the TonoVet tonometer is best for use in rabbits while the TonoLab should be avoided. The impact of sedation on IOP was substantial and should be taken into account during experimentation.Christian J. F. BertensRalph J. S. van MechelenTos T. J. M. BerendschotMarlies GijsJarno E. J. WoltersTheo G. M. F. GorgelsRudy M. M. A. NuijtsHenny J. M. BeckersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian J. F. Bertens Ralph J. S. van Mechelen Tos T. J. M. Berendschot Marlies Gijs Jarno E. J. Wolters Theo G. M. F. Gorgels Rudy M. M. A. Nuijts Henny J. M. Beckers Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
description	Abstract The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbits with the TonoVet tonometer. Repeatability was determined using the coefficient of variation (CoV) for two observers. For the TonoLab (6.55%) and TonoVet (6.38%) the CoV was lower than for the TonoPEN AVIA (10.88%). The reproducibility was highest for the TonoVet (0.2 ± 3.3 mmHg), followed by the TonoLab (0 ± 12.89 mmHg) and lowest for the TonoPEN AVIA (− 1.48 ± 10.3 mmHg). The TonoLab and TonoVet showed the highest agreement (r = 0.85, R2 = 0.73). After sedation, a significant IOP reduction (often > 25%) was observed. Our results show that among the three tonometers tested, the TonoVet tonometer is best for use in rabbits while the TonoLab should be avoided. The impact of sedation on IOP was substantial and should be taken into account during experimentation.
format	article
author	Christian J. F. Bertens Ralph J. S. van Mechelen Tos T. J. M. Berendschot Marlies Gijs Jarno E. J. Wolters Theo G. M. F. Gorgels Rudy M. M. A. Nuijts Henny J. M. Beckers
author_facet	Christian J. F. Bertens Ralph J. S. van Mechelen Tos T. J. M. Berendschot Marlies Gijs Jarno E. J. Wolters Theo G. M. F. Gorgels Rudy M. M. A. Nuijts Henny J. M. Beckers
author_sort	Christian J. F. Bertens
title	Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
title_short	Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
title_full	Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
title_fullStr	Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
title_full_unstemmed	Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
title_sort	repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dc4b4f9e4dab455facc220f13d94f395
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Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits

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