Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Yi Zhang, Jiayao Bi, Jiayi Huang, Yanan Tang, Shouying Du, Pengyue Li School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Pengyue Li Email lipengyuetougao@126.comAbstract: Exosomes are nano-sized small extracellular v...

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Autores principales:	Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	exosomes extraction and purification storage stability biomarkers targeted drug delivery surface modification Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dc4bf1d182484b0e9efb628d71cc16bb
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spelling	oai:doaj.org-article:dc4bf1d182484b0e9efb628d71cc16bb2021-12-02T11:05:00ZExosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications1178-2013https://doaj.org/article/dc4bf1d182484b0e9efb628d71cc16bb2020-09-01T00:00:00Zhttps://www.dovepress.com/exosome-a-review-of-its-classification-isolation-techniques-storage-di-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yi Zhang, Jiayao Bi, Jiayi Huang, Yanan Tang, Shouying Du, Pengyue Li School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Pengyue Li Email lipengyuetougao@126.comAbstract: Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body’s physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.Keywords: exosomes, extraction and purification, storage stability, biomarkers, targeted drug delivery, surface modificationZhang YBi JHuang JTang YDu SLi PDove Medical Pressarticleexosomesextraction and purificationstorage stabilitybiomarkerstargeted drug deliverysurface modificationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6917-6934 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes extraction and purification storage stability biomarkers targeted drug delivery surface modification Medicine (General) R5-920
spellingShingle	exosomes extraction and purification storage stability biomarkers targeted drug delivery surface modification Medicine (General) R5-920 Zhang Y Bi J Huang J Tang Y Du S Li P Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
description	Yi Zhang, Jiayao Bi, Jiayi Huang, Yanan Tang, Shouying Du, Pengyue Li School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Pengyue Li Email lipengyuetougao@126.comAbstract: Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body’s physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.Keywords: exosomes, extraction and purification, storage stability, biomarkers, targeted drug delivery, surface modification
format	article
author	Zhang Y Bi J Huang J Tang Y Du S Li P
author_facet	Zhang Y Bi J Huang J Tang Y Du S Li P
author_sort	Zhang Y
title	Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
title_short	Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
title_full	Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
title_fullStr	Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
title_full_unstemmed	Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications
title_sort	exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/dc4bf1d182484b0e9efb628d71cc16bb
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Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

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